Reference - Detail
| RRC ID | 11291 |
|---|---|
| Author | Masumoto M, Yaginuma T, Niimi T. |
| Title | Functional analysis of Ultrabithorax in the silkworm, Bombyx mori, using RNAi. |
| Journal | Dev Genes Evol |
| Abstract |
The formation of abdominal appendages in insects is suppressed by the Hox genes Ultrabithorax (Ubx) and abdominal-A (abd-A), but mechanisms of the suppression can differ among species. As the function of Ubx and abd-A has been described in only a few species, more data from various insects are necessary to elucidate the evolutionary transition of regulation on abdominal appendages. We examined the function of Ubx in the silkworm Bombyx mori (Bm-Ubx) by embryonic RNA interference (RNAi). This is the first case in which functional analysis for Ubx is performed in lepidopteran insects. Larvae treated with Bm-Ubx dsRNA displayed an additional pair of thoracic leg-like protuberances in A1, whereas the other abdominal segments had no transformation. Our results suggest that Bm-Ubx is a suppressor of leg development in A1. |
| Volume | 219(9-10) |
| Pages | 437-44 |
| Published | 2009-10-1 |
| DOI | 10.1007/s00427-009-0305-9 |
| PMID | 19908062 |
| MeSH | Amino Acid Sequence Animals Base Sequence Bombyx / genetics Bombyx / growth & development Bombyx / metabolism* Cloning, Molecular Extremities / growth & development Genes, Homeobox Homeodomain Proteins / chemistry Homeodomain Proteins / genetics Homeodomain Proteins / metabolism* Molecular Sequence Data RNA Interference |
| IF | 1.339 |
| Times Cited | 28 |
| WOS Category | EVOLUTIONARY BIOLOGY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| Resource | |
| Silkworms | |