| RRC ID |
1130
|
| Author |
Kasai Y, Komatsu K, Shigemori H, Tsuda M, Mikami Y, Kobayashi J.
|
| Title |
Cladionol A, a polyketide glycoside from marine-derived fungus Gliocladium species.
|
| Journal |
J Nat Prod
|
| Abstract |
A new polyketide glycoside, cladionol A (1), was isolated from the cultured broth of a fungus Gliocladium sp., which was separated from sea grass Syringodium isoetifolium, and the structure was elucidated by spectroscopic data. The relative stereochemistry of C-2-C-3 was assigned by mainly J-based configuration analysis, while those of two sugar units were elucidated to be beta-mannopyranoside and arabitol on the basis of NOESY data and/or 1H-1H couplings. Furthermore, the absolute configuration of the mannose moiety was determined as the D-form on the basis of chiral HPLC analysis of a benzoyl derivative of the acid hydrolysate of 1. Cladionol A (1) exhibited modest cytotoxicity.
|
| Volume |
68(5)
|
| Pages |
777-9
|
| Published |
2005-5-1
|
| DOI |
10.1021/np050046b
|
| PMID |
15921429
|
| MeSH |
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Gliocladium / chemistry*
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology
Japan
Models, Molecular
Molecular Structure
|
| IF |
3.782
|
| Times Cited |
28
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
PLANT SCIENCES
CHEMISTRY, MEDICINAL
|
| Resource |
| Pathogenic microorganisms |
|
