RRC ID 1132
Author Mukai A, Yazawa K, Mikami Y, Harada K, Gräfe U.
Title Biotransformation of bile acids by pathogenic actinomycetes Nocardia otitidiscaviarum and Amycolatopsis sp. strains.
Journal J. Antibiot.
Abstract Three sterol-type compounds (compounds 4, 5 and 6) were isolated from culture broth of pathogenic Nocardia otitidiscaviarum IFM 0988 and Amycolatopsis sp. IFM 0703 strains which were isolated from Japanese patients. The structures of the compounds were determined by NMR and mass spectrometric analyses. The structural studies indicated that compound 4 is a biotransformation product from cholic acid derivative in a nutrient culture medium constituent by a reductase-type enzyme, and the remaining two compounds 5 and 6 are also biotransformation ones by oxidase-type enzymes.
Volume 58(5)
Pages 356-60
Published 2005-5
DOI 10.1038/ja.2005.46
PMID 16060390
MeSH Actinobacteria / metabolism* Bile Acids and Salts / metabolism* Biotransformation Cholic Acid / metabolism Chromatography, Liquid Culture Media Fermentation Magnetic Resonance Spectroscopy Mass Spectrometry Nocardia / metabolism* Oxidoreductases / metabolism
IF 2.033
Times Cited 4
WOS Category BIOTECHNOLOGY & APPLIED MICROBIOLOGY PHARMACOLOGY & PHARMACY IMMUNOLOGY MICROBIOLOGY
Resource
Pathogenic microorganisms IFM 0988 IFM 0703