RRC ID 11327
Author Arunkumar KP, Mita K, Nagaraju J.
Title The silkworm Z chromosome is enriched in testis-specific genes.
Journal Genetics
Abstract The role of sex chromosomes in sex determination has been well studied in diverse groups of organisms. However, the role of the genes on the sex chromosomes in conferring sexual dimorphism is still being experimentally evaluated. An unequal complement of sex chromosomes between two sexes makes them amenable to sex-specific evolutionary forces. Sex-linked genes preferentially expressed in one sex over the other offer a potential means of addressing the role of sex chromosomes in sexual dimorphism. We examined the testis transcriptome of the silkworm, Bombyx mori, which has a ZW chromosome constitution in the female and ZZ in the male, and show that the Z chromosome harbors a significantly higher number of genes expressed preferentially in testis compared to the autosomes. We hypothesize that sexual antagonism and absence of dosage compensation have possibly led to the accumulation of many male-specific genes on the Z chromosome. Further, our analysis of testis-specific paralogous genes suggests that the accumulation on the Z chromosome of genes advantageous to males has occurred primarily by translocation or tandem duplication.
Volume 182(2)
Pages 493-501
Published 2009-6-1
DOI 10.1534/genetics.108.099994
PII genetics.108.099994
PMID 19332883
PMC PMC2691758
MeSH Animals Bombyx / genetics* Computational Biology Conserved Sequence Expressed Sequence Tags Female Gene Expression Profiling Genes, Insect / genetics* Genetic Variation Humans Male Organ Specificity / genetics Physical Chromosome Mapping Sex Chromosomes / genetics* Testis / metabolism* Translocation, Genetic
IF 4.015
Times Cited 58
Silkworms ?