論文 - 詳細
| RRC ID | 1132 |
|---|---|
| 著者 | Mukai A, Yazawa K, Mikami Y, Harada K, Gräfe U. |
| タイトル | Biotransformation of bile acids by pathogenic actinomycetes Nocardia otitidiscaviarum and Amycolatopsis sp. strains. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
Three sterol-type compounds (compounds 4, 5 and 6) were isolated from culture broth of pathogenic Nocardia otitidiscaviarum IFM 0988 and Amycolatopsis sp. IFM 0703 strains which were isolated from Japanese patients. The structures of the compounds were determined by NMR and mass spectrometric analyses. The structural studies indicated that compound 4 is a biotransformation product from cholic acid derivative in a nutrient culture medium constituent by a reductase-type enzyme, and the remaining two compounds 5 and 6 are also biotransformation ones by oxidase-type enzymes. |
| 巻・号 | 58(5) |
| ページ | 356-60 |
| 公開日 | 2005-5-1 |
| DOI | 10.1038/ja.2005.46 |
| PMID | 16060390 |
| MeSH | Actinobacteria / metabolism* Bile Acids and Salts / metabolism* Biotransformation Cholic Acid / metabolism Chromatography, Liquid Culture Media Fermentation Magnetic Resonance Spectroscopy Mass Spectrometry Nocardia / metabolism* Oxidoreductases / metabolism |
| IF | 2.668 |
| 引用数 | 4 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY PHARMACOLOGY & PHARMACY IMMUNOLOGY MICROBIOLOGY |
| リソース情報 | |
| 病原微生物 | IFM 0988 IFM 0703 |