論文 - 詳細
| RRC ID | 11348 |
|---|---|
| 著者 | Mata J, Lyne R, Burns G, Bähler J. |
| タイトル | The transcriptional program of meiosis and sporulation in fission yeast. |
| ジャーナル | Nat Genet |
| Abstract |
Sexual reproduction requires meiosis to produce haploid gametes, which in turn can fuse to regenerate a diploid organism. We have studied the transcriptional program that drives this developmental process in Schizosaccharomyces pombe using DNA microarrays. Here we show that hundreds of genes are regulated in successive waves of transcription that correlate with major biological events of meiosis and sporulation. Each wave is associated with specific promoter motifs. Clusters of neighboring genes (mostly close to telomeres) are co-expressed early in the process, which reflects a more global control of these genes. We find that two Atf-like transcription factors are essential for the expression of late genes and formation of spores, and identify dozens of potential Atf target genes. Comparison with the meiotic program of the distantly related Saccharomyces cerevisiae reveals an unexpectedly small shared meiotic transcriptome, suggesting that the transcriptional regulation of meiosis evolved independently in both species. |
| 巻・号 | 32(1) |
| ページ | 143-7 |
| 公開日 | 2002-9-1 |
| DOI | 10.1038/ng951 |
| PII | ng951 |
| PMID | 12161753 |
| MeSH | Activating Transcription Factors Blood Proteins / genetics Blood Proteins / metabolism Fungal Proteins / metabolism Gene Expression Profiling Gene Expression Regulation, Fungal* Meiosis / physiology* Nuclear Proteins Saccharomyces cerevisiae Proteins* Schizosaccharomyces / genetics Schizosaccharomyces / physiology* Schizosaccharomyces pombe Proteins* Spores, Fungal / physiology* Transcription Factors / genetics Transcription Factors / metabolism Transcription, Genetic* |
| IF | 27.605 |
| 引用数 | 362 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | strains? |