| RRC ID |
11348
|
| 著者 |
Mata J, Lyne R, Burns G, Bähler J.
|
| タイトル |
The transcriptional program of meiosis and sporulation in fission yeast.
|
| ジャーナル |
Nat Genet
|
| Abstract |
Sexual reproduction requires meiosis to produce haploid gametes, which in turn can fuse to regenerate a diploid organism. We have studied the transcriptional program that drives this developmental process in Schizosaccharomyces pombe using DNA microarrays. Here we show that hundreds of genes are regulated in successive waves of transcription that correlate with major biological events of meiosis and sporulation. Each wave is associated with specific promoter motifs. Clusters of neighboring genes (mostly close to telomeres) are co-expressed early in the process, which reflects a more global control of these genes. We find that two Atf-like transcription factors are essential for the expression of late genes and formation of spores, and identify dozens of potential Atf target genes. Comparison with the meiotic program of the distantly related Saccharomyces cerevisiae reveals an unexpectedly small shared meiotic transcriptome, suggesting that the transcriptional regulation of meiosis evolved independently in both species.
|
| 巻・号 |
32(1)
|
| ページ |
143-7
|
| 公開日 |
2002-9-1
|
| DOI |
10.1038/ng951
|
| PII |
ng951
|
| PMID |
12161753
|
| MeSH |
Activating Transcription Factors
Blood Proteins / genetics
Blood Proteins / metabolism
Fungal Proteins / metabolism
Gene Expression Profiling
Gene Expression Regulation, Fungal*
Meiosis / physiology*
Nuclear Proteins
Saccharomyces cerevisiae Proteins*
Schizosaccharomyces / genetics
Schizosaccharomyces / physiology*
Schizosaccharomyces pombe Proteins*
Spores, Fungal / physiology*
Transcription Factors / genetics
Transcription Factors / metabolism
Transcription, Genetic*
|
| IF |
27.605
|
| 引用数 |
362
|
|
WOS 分野
|
GENETICS & HEREDITY
|
| リソース情報 |
| 酵母 |
strains? |
