Reference - Detail
|Author||Ito M, Deguchi T, Mizutani KS, Yasuda M, Yokoi S, Ito S, Takahashi Y, Ishihara S, Kawamura Y, Ezaki T.|
|Title||Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan.|
|Journal||Antimicrob. Agents Chemother.|
or =1 microg/ml. Analysis of chromosomal DNA restriction patterns by pulsed-field gel electrophoresis revealed that most isolates with the mosaic PBP 2 were genetically similar. The recombination events that generated the mosaic PBP 2 would likely have contributed to the decreased sensitivities to cephalosporins. Isolates with the mosaic PBP 2 appear to threaten the efficacy of the currently recommended regimen with cefixime. The emergence of such strains may be the result of the in vivo generation of clones in which interspecies recombination occurred between the penA genes of N. gonorrhoeae and commensal Neisseria species.
|MeSH||Amino Acid Sequence Amino Acid Substitution Anti-Bacterial Agents / pharmacology Cefixime / pharmacology Drug Resistance, Bacterial Electrophoresis, Gel, Pulsed-Field Gonorrhea / epidemiology* Gonorrhea / microbiology Gonorrhea / transmission* Humans Japan / epidemiology Male Microbial Sensitivity Tests Molecular Sequence Data Neisseria / genetics Neisseria / metabolism Neisseria gonorrhoeae / drug effects* Neisseria gonorrhoeae / genetics Neisseria gonorrhoeae / isolation & purification Neisseria gonorrhoeae / metabolism Penicillin-Binding Proteins / chemistry Penicillin-Binding Proteins / genetics* Recombination, Genetic*|
|WOS Category||PHARMACOLOGY & PHARMACY MICROBIOLOGY|
|Pathogenic microorganisms||N. gonorrhoeae?|