RRC ID 11433
Author Chen PJ, Su CH, Tseng CY, Tan SW, Cheng CH.
Title Toxicity assessments of nanoscale zerovalent iron and its oxidation products in medaka (Oryzias latipes) fish.
Journal Mar Pollut Bull
Abstract Iron-based nanotechnologies are increasingly used for environmental remediation; however, toxicologic impacts of iron nanoparticles on the aquatic ecosystem remain poorly understood. We treated larvae of medaka fish (Oryzias latipes) with thoroughly characterized solutions containing carboxymethyl cellulose (CMC)-stabilized nanoscale zerovalent iron (nZVI), aged nanoscale iron oxides (nFe-oxides) or ferrous ion (Fe[II]) for 12-14 days' aqueous exposure to assess the causal toxic effect(s) of iron NPs on the fish. With the CMC-nZVI solution, the dissolved oxygen level decreased, and a burst of reactive oxygen species (ROS) was generated as Fe(II) oxidized to ferric ion (Fe[III]); with the other two iron solutions, these parameters did not significantly change. CMC-nZVI and Fe(II) solutions caused acute lethally and sublethally toxic effects in medaka larvae, with nFe-oxide-containing solutions causing the least toxic effects. We discuss modes of toxic action of iron NPs and chronic toxic effects in terms of hypoxia, Fe(II) toxicity and ROS-mediated oxidative damage.
Volume 63(5-12)
Pages 339-46
Published 2011-1-1
DOI 10.1016/j.marpolbul.2011.02.045
PII S0025-326X(11)00116-0
PMID 21440267
MeSH Animals Dose-Response Relationship, Drug Environmental Restoration and Remediation Gene Expression / drug effects Iron / chemistry Iron / toxicity* Larva / drug effects Metal Nanoparticles / chemistry Metal Nanoparticles / toxicity* Oryzias Oxidative Stress Reactive Oxygen Species / metabolism Water Pollutants, Chemical / chemistry Water Pollutants, Chemical / toxicity*
IF 4.049
Times Cited 53