| RRC ID |
11433
|
| 著者 |
Chen PJ, Su CH, Tseng CY, Tan SW, Cheng CH.
|
| タイトル |
Toxicity assessments of nanoscale zerovalent iron and its oxidation products in medaka (Oryzias latipes) fish.
|
| ジャーナル |
Mar Pollut Bull
|
| Abstract |
Iron-based nanotechnologies are increasingly used for environmental remediation; however, toxicologic impacts of iron nanoparticles on the aquatic ecosystem remain poorly understood. We treated larvae of medaka fish (Oryzias latipes) with thoroughly characterized solutions containing carboxymethyl cellulose (CMC)-stabilized nanoscale zerovalent iron (nZVI), aged nanoscale iron oxides (nFe-oxides) or ferrous ion (Fe[II]) for 12-14 days' aqueous exposure to assess the causal toxic effect(s) of iron NPs on the fish. With the CMC-nZVI solution, the dissolved oxygen level decreased, and a burst of reactive oxygen species (ROS) was generated as Fe(II) oxidized to ferric ion (Fe[III]); with the other two iron solutions, these parameters did not significantly change. CMC-nZVI and Fe(II) solutions caused acute lethally and sublethally toxic effects in medaka larvae, with nFe-oxide-containing solutions causing the least toxic effects. We discuss modes of toxic action of iron NPs and chronic toxic effects in terms of hypoxia, Fe(II) toxicity and ROS-mediated oxidative damage.
|
| 巻・号 |
63(5-12)
|
| ページ |
339-46
|
| 公開日 |
2011-1-1
|
| DOI |
10.1016/j.marpolbul.2011.02.045
|
| PII |
S0025-326X(11)00116-0
|
| PMID |
21440267
|
| MeSH |
Animals
Dose-Response Relationship, Drug
Environmental Restoration and Remediation
Gene Expression / drug effects
Iron / chemistry
Iron / toxicity*
Larva / drug effects
Metal Nanoparticles / chemistry
Metal Nanoparticles / toxicity*
Oryzias
Oxidative Stress
Reactive Oxygen Species / metabolism
Water Pollutants, Chemical / chemistry
Water Pollutants, Chemical / toxicity*
|
| IF |
4.049
|
| 引用数 |
53
|
|
WOS 分野
|
MARINE & FRESHWATER BIOLOGY
ENVIRONMENTAL SCIENCES
|
| リソース情報 |
| メダカ |
|
