| RRC ID |
11590
|
| Author |
Huang Z, Yazdani U, Thompson-Peer KL, Kolodkin AL, Terman JR.
|
| Title |
Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development.
|
| Journal |
Development
|
| Abstract |
Members of the Cas family of Src homology 3 (SH3)-domain-containing cytosolic signaling proteins are crucial regulators of actin cytoskeletal dynamics in non-neuronal cells; however, their neuronal functions are poorly understood. Here, we identify a Drosophila Cas (DCas), find that Cas proteins are highly expressed in neurons and show that DCas is required for correct axon guidance during development. Functional analyses reveal that Cas specifies axon guidance by regulating the degree of fasciculation among axons. These guidance defects are similar to those observed in integrin mutants, and genetic analysis shows that integrins function together with Cas to facilitate axonal defasciculation. These results strongly support Cas proteins working together with integrins in vivo to direct axon guidance events.
|
| Volume |
134(12)
|
| Pages |
2337-47
|
| Published |
2007-6-1
|
| DOI |
10.1242/dev.004242
|
| PII |
134/12/2337
|
| PMID |
17537798
|
| MeSH |
Amino Acid Motifs
Amino Acid Sequence
Animals
Axons / physiology*
Binding Sites
Conserved Sequence
Crk-Associated Substrate Protein / metabolism
Crk-Associated Substrate Protein / physiology*
Drosophila / embryology
Drosophila / genetics
Embryo, Nonmammalian
Embryonic Development*
Immunohistochemistry
In Situ Hybridization
Integrins / physiology*
Models, Biological
Molecular Sequence Data
Neurons / metabolism
Protein Binding
Sequence Homology, Amino Acid
Signal Transduction*
|
| IF |
5.611
|
| Times Cited |
22
|
|
WOS Category
|
DEVELOPMENTAL BIOLOGY
|
| Resource |
| Drosophila |
DGRC#104686 |
