論文 - 詳細
| RRC ID | 11590 |
|---|---|
| 著者 | Huang Z, Yazdani U, Thompson-Peer KL, Kolodkin AL, Terman JR. |
| タイトル | Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development. |
| ジャーナル | Development |
| Abstract |
Members of the Cas family of Src homology 3 (SH3)-domain-containing cytosolic signaling proteins are crucial regulators of actin cytoskeletal dynamics in non-neuronal cells; however, their neuronal functions are poorly understood. Here, we identify a Drosophila Cas (DCas), find that Cas proteins are highly expressed in neurons and show that DCas is required for correct axon guidance during development. Functional analyses reveal that Cas specifies axon guidance by regulating the degree of fasciculation among axons. These guidance defects are similar to those observed in integrin mutants, and genetic analysis shows that integrins function together with Cas to facilitate axonal defasciculation. These results strongly support Cas proteins working together with integrins in vivo to direct axon guidance events. |
| 巻・号 | 134(12) |
| ページ | 2337-47 |
| 公開日 | 2007-6-1 |
| DOI | 10.1242/dev.004242 |
| PII | 134/12/2337 |
| PMID | 17537798 |
| MeSH | Amino Acid Motifs Amino Acid Sequence Animals Axons / physiology* Binding Sites Conserved Sequence Crk-Associated Substrate Protein / metabolism Crk-Associated Substrate Protein / physiology* Drosophila / embryology Drosophila / genetics Embryo, Nonmammalian Embryonic Development* Immunohistochemistry In Situ Hybridization Integrins / physiology* Models, Biological Molecular Sequence Data Neurons / metabolism Protein Binding Sequence Homology, Amino Acid Signal Transduction* |
| IF | 5.611 |
| 引用数 | 22 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#104686 |