Reference - Detail
| RRC ID | 11607 |
|---|---|
| Author | Tsuda M, Sugiura T, Ishii T, Ishii N, Aigaki T. |
| Title | A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Oxidative stress is thought to promote aging by damaging various cellular components. We investigated the phenotypic effects of mutation in the sdhC gene encoding succinate dehydrogenase C in Drosophila by using transgenic flies expressing a dominant-negative form, SdhC(I71E). Expression of SdhC(I71E) significantly reduced the mean lifespan by 22% compared to that of control flies. The amount of protein carbonyl was significantly increased, suggesting that a high level of oxidative stress was induced in these flies. The transgenic flies should serve as a model for studying the biological processes associated with increased levels of oxidative stress and mitochondrial dysfunction in Drosophila. |
| Volume | 363(2) |
| Pages | 342-6 |
| Published | 2007-11-16 |
| DOI | 10.1016/j.bbrc.2007.08.168 |
| PII | S0006-291X(07)01899-2 |
| PMID | 17854771 |
| MeSH | Animals Bacterial Proteins / genetics Bacterial Proteins / metabolism* Caenorhabditis elegans Proteins / metabolism* Cytochromes b Drosophila / physiology* Longevity / physiology* Oxidative Stress / physiology* Succinate Dehydrogenase / metabolism* |
| IF | 2.985 |
| Times Cited | 16 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Drosophila | |