| RRC ID |
11616
|
| Author |
Kucherenko MM, Pantoja M, Yatsenko AS, Shcherbata HR, Fischer KA, Maksymiv DV, Chernyk YI, Ruohola-Baker H.
|
| Title |
Genetic modifier screens reveal new components that interact with the Drosophila dystroglycan-dystrophin complex.
|
| Journal |
PLoS One
|
| Abstract |
The Dystroglycan-Dystrophin (Dg-Dys) complex has a capacity to transmit information from the extracellular matrix to the cytoskeleton inside the cell. It is proposed that this interaction is under tight regulation; however the signaling/regulatory components of Dg-Dys complex remain elusive. Understanding the regulation of the complex is critical since defects in this complex cause muscular dystrophy in humans. To reveal new regulators of the Dg-Dys complex, we used a model organism Drosophila melanogaster and performed genetic interaction screens to identify modifiers of Dg and Dys mutants in Drosophila wing veins. These mutant screens revealed that the Dg-Dys complex interacts with genes involved in muscle function and components of Notch, TGF-beta and EGFR signaling pathways. In addition, components of pathways that are required for cellular and/or axonal migration through cytoskeletal regulation, such as Semaphorin-Plexin, Frazzled-Netrin and Slit-Robo pathways show interactions with Dys and/or Dg. These data suggest that the Dg-Dys complex and the other pathways regulating extracellular information transfer to the cytoskeletal dynamics are more intercalated than previously thought.
|
| Volume |
3(6)
|
| Pages |
e2418
|
| Published |
2008-6-11
|
| DOI |
10.1371/journal.pone.0002418
|
| PMID |
18545683
|
| PMC |
PMC2398783
|
| MeSH |
Animals
Drosophila Proteins / metabolism
Drosophila melanogaster / genetics*
Drosophila melanogaster / metabolism
Dystroglycans / metabolism*
Dystrophin / metabolism*
ErbB Receptors / metabolism
Mutation
Receptors, Notch / metabolism
Signal Transduction
Transforming Growth Factor beta / metabolism
|
| IF |
2.74
|
| Times Cited |
43
|
|
WOS Category
|
CELL BIOLOGY
|
| Resource |
| Drosophila |
FRT-lethal |
