論文 - 詳細
| RRC ID | 11642 |
|---|---|
| 著者 | Roegiers F, Kavaler J, Tolwinski N, Chou YT, Duan H, Bejarano F, Zitserman D, Lai EC. |
| タイトル | Frequent unanticipated alleles of lethal giant larvae in Drosophila second chromosome stocks. |
| ジャーナル | Genetics |
| Abstract |
Forty years ago, a high frequency of lethal giant larvae (lgl) alleles in wild populations of Drosophila melanogaster was reported. This locus has been intensively studied for its roles in epithelial polarity, asymmetric neural divisions, and restriction of tissue proliferation. Here, we identify a high frequency of lgl alleles in the Bloomington second chromosome deficiency kit and the University of California at Los Angeles Bruinfly FRT40A-lethal P collection. These unrecognized aberrations confound the use of these workhorse collections for phenotypic screening or genetic mapping. In addition, we determined that independent alleles of insensitive, reported to affect asymmetric cell divisions during sensory organ development, carry lgl deletions that are responsible for the observed phenotypes. Taken together, these results encourage the routine testing of second chromosome stocks for second-site alleles of lgl. |
| 巻・号 | 182(1) |
| ページ | 407-10 |
| 公開日 | 2009-5-1 |
| DOI | 10.1534/genetics.109.101808 |
| PII | genetics.109.101808 |
| PMID | 19279324 |
| PMC | PMC2674838 |
| MeSH | Alleles* Animals Chromosome Aberrations* Drosophila Proteins / genetics* Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Genes, Lethal / genetics* Tumor Suppressor Proteins / genetics* |
| IF | 4.015 |
| 引用数 | 19 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | FRT-lethal |