論文 - 詳細
| RRC ID | 11666 |
|---|---|
| 著者 | Koana T, Tsujimura H. |
| タイトル | A U-shaped dose-response relationship between x radiation and sex-linked recessive lethal mutation in male germ cells of Drosophila. |
| ジャーナル | Radiat Res |
| Abstract |
We reported previously that low-dose X irradiation of DNA repair-proficient immature sperm of wild-type Drosophila melanogaster at a low dose rate (50 mGy/min) resulted in a mutation frequency that was lower than that in the sham-irradiated group. Therefore, a U-shaped dose-response relationship was suggested. Here we show that the dose-response curve is actually U-shaped by carrying out a large-scale sex-linked recessive lethal assay using Drosophila. No reduction of the mutation frequency was observed in a strain mutant for the nucleotide excision repair gene mei-9a (Drosophila homologue of human XPF). Introduction of a chromosome fragment containing mei-9+ into the mei-9a mutant strain restored the reduction of the mutation frequency in the low-dose-irradiated group. These results showed that DNA repair was responsible for the U-shaped dose-response relationship in Drosophila. |
| 巻・号 | 174(1) |
| ページ | 46-51 |
| 公開日 | 2010-7-1 |
| DOI | 10.1667/RR2085.1 |
| PMID | 20681798 |
| MeSH | Animals Dose-Response Relationship, Drug Drosophila melanogaster / genetics* Drosophila melanogaster / radiation effects Female Genes, Lethal* Genes, Recessive* In Situ Nick-End Labeling Male Mutation* Spermatozoa / radiation effects* |
| IF | 2.657 |
| 引用数 | 15 |
| WOS 分野 | BIOLOGY RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BIOPHYSICS |
| リソース情報 | |
| ショウジョウバエ | Dp(1 2) 4FRDup/+ carrying stock |