論文 - 詳細
RRC ID | 11666 |
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著者 | Koana T, Tsujimura H. |
タイトル | A U-shaped dose-response relationship between x radiation and sex-linked recessive lethal mutation in male germ cells of Drosophila. |
ジャーナル | Radiat Res |
Abstract |
We reported previously that low-dose X irradiation of DNA repair-proficient immature sperm of wild-type Drosophila melanogaster at a low dose rate (50 mGy/min) resulted in a mutation frequency that was lower than that in the sham-irradiated group. Therefore, a U-shaped dose-response relationship was suggested. Here we show that the dose-response curve is actually U-shaped by carrying out a large-scale sex-linked recessive lethal assay using Drosophila. No reduction of the mutation frequency was observed in a strain mutant for the nucleotide excision repair gene mei-9a (Drosophila homologue of human XPF). Introduction of a chromosome fragment containing mei-9+ into the mei-9a mutant strain restored the reduction of the mutation frequency in the low-dose-irradiated group. These results showed that DNA repair was responsible for the U-shaped dose-response relationship in Drosophila. |
巻・号 | 174(1) |
ページ | 46-51 |
公開日 | 2010-7-1 |
DOI | 10.1667/RR2085.1 |
PMID | 20681798 |
MeSH | Animals Dose-Response Relationship, Drug Drosophila melanogaster / genetics* Drosophila melanogaster / radiation effects Female Genes, Lethal* Genes, Recessive* In Situ Nick-End Labeling Male Mutation* Spermatozoa / radiation effects* |
IF | 2.657 |
引用数 | 15 |
WOS 分野 | BIOLOGY RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BIOPHYSICS |
リソース情報 | |
ショウジョウバエ | Dp(1 2) 4FRDup/+ carrying stock |