論文 - 詳細
| RRC ID | 11668 |
|---|---|
| 著者 | Kondo T, Plaza S, Zanet J, Benrabah E, Valenti P, Hashimoto Y, Kobayashi S, Payre F, Kageyama Y. |
| タイトル | Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis. |
| ジャーナル | Science |
| Abstract |
A substantial proportion of eukaryotic transcripts are considered to be noncoding RNAs because they contain only short open reading frames (sORFs). Recent findings suggest, however, that some sORFs encode small bioactive peptides. Here, we show that peptides of 11 to 32 amino acids encoded by the polished rice (pri) sORF gene control epidermal differentiation in Drosophila by modifying the transcription factor Shavenbaby (Svb). Pri peptides trigger the amino-terminal truncation of the Svb protein, which converts Svb from a repressor to an activator. Our results demonstrate that during Drosophila embryogenesis, Pri sORF peptides provide a strict temporal control to the transcriptional program of epidermal morphogenesis. |
| 巻・号 | 329(5989) |
| ページ | 336-9 |
| 公開日 | 2010-7-16 |
| DOI | 10.1126/science.1188158 |
| PII | 329/5989/336 |
| PMID | 20647469 |
| MeSH | Animals Cell Differentiation Cell Nucleus / metabolism DNA-Binding Proteins / chemistry DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Drosophila Proteins / chemistry Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / embryology Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Embryo, Nonmammalian / cytology Embryo, Nonmammalian / metabolism* Embryonic Development Epidermal Cells Epidermis / metabolism Gene Expression Regulation, Developmental* Genes, Insect Mutation Open Reading Frames Peptides / genetics Peptides / metabolism* Protein Isoforms / chemistry Protein Isoforms / genetics Protein Isoforms / metabolism Protein Processing, Post-Translational Protein Structure, Tertiary RNA, Untranslated / genetics Recombinant Fusion Proteins / metabolism Transcription Factors / chemistry Transcription Factors / genetics Transcription Factors / metabolism* Transcription, Genetic* |
| IF | 41.846 |
| 引用数 | 207 |
| WOS 分野 | MULTIDISCIPLINARY SCIENCES |
| リソース情報 | |
| ショウジョウバエ | |