| RRC ID |
11689
|
| 著者 |
Tsuda M, Kobayashi T, Matsuo T, Aigaki T.
|
| タイトル |
Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
Insulin-degrading enzyme (IDE) is implicated in the pathogenesis of type 2 diabetes mellitus (DM2) and Alzheimer's disease (AD). Here we provide genetic evidence that Drosophila Ide (dIde) antagonizes the insulin signaling pathway and human Abeta-induced neurotoxicity in Drosophila. In this study, we also generated a dIde knockout mutant (dIde(KO)) by gene targeting, and found that loss of IDE increases the content of the major insect blood sugar, trehalose, thus suggesting a conserved role of IDE in sugar metabolism. Using dIde(KO) as a model, further investigations into the biological functions of IDE and its role in the pathogenesis of DM2 and AD can be made.
|
| 巻・号 |
584(13)
|
| ページ |
2916-20
|
| 公開日 |
2010-7-2
|
| DOI |
10.1016/j.febslet.2010.05.010
|
| PII |
S0014-5793(10)00403-5
|
| PMID |
20493190
|
| MeSH |
Alzheimer Disease / metabolism
Amyloid beta-Peptides / genetics
Amyloid beta-Peptides / metabolism*
Animals
Animals, Genetically Modified
Body Weight
Disease Models, Animal
Drosophila
Female
Glucose / metabolism
Hemolymph / metabolism
Humans
Insulysin / genetics
Insulysin / metabolism*
Male
Neurons / metabolism*
Trehalose / metabolism
|
| IF |
3.057
|
| 引用数 |
17
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
Act5C-GAL4 and UAS-mCD8::GFP |
