論文 - 詳細
| RRC ID | 11689 |
|---|---|
| 著者 | Tsuda M, Kobayashi T, Matsuo T, Aigaki T. |
| タイトル | Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila. |
| ジャーナル | FEBS Lett |
| Abstract |
Insulin-degrading enzyme (IDE) is implicated in the pathogenesis of type 2 diabetes mellitus (DM2) and Alzheimer's disease (AD). Here we provide genetic evidence that Drosophila Ide (dIde) antagonizes the insulin signaling pathway and human Abeta-induced neurotoxicity in Drosophila. In this study, we also generated a dIde knockout mutant (dIde(KO)) by gene targeting, and found that loss of IDE increases the content of the major insect blood sugar, trehalose, thus suggesting a conserved role of IDE in sugar metabolism. Using dIde(KO) as a model, further investigations into the biological functions of IDE and its role in the pathogenesis of DM2 and AD can be made. |
| 巻・号 | 584(13) |
| ページ | 2916-20 |
| 公開日 | 2010-7-2 |
| DOI | 10.1016/j.febslet.2010.05.010 |
| PII | S0014-5793(10)00403-5 |
| PMID | 20493190 |
| MeSH | Alzheimer Disease / metabolism Amyloid beta-Peptides / genetics Amyloid beta-Peptides / metabolism* Animals Animals, Genetically Modified Body Weight Disease Models, Animal Drosophila Female Glucose / metabolism Hemolymph / metabolism Humans Insulysin / genetics Insulysin / metabolism* Male Neurons / metabolism* Trehalose / metabolism |
| IF | 3.057 |
| 引用数 | 17 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ショウジョウバエ | Act5C-GAL4 and UAS-mCD8::GFP |