論文 - 詳細
| RRC ID | 11772 |
|---|---|
| 著者 | Takahashi E, Niimi K. |
| タイトル | Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya. |
| ジャーナル | Exp Gerontol |
| Abstract |
Rolling Nagoya mice carrying Ca(v)2.1alpha1 gene mutation show ataxia, whereas heterozygous mice show no apparently abnormal behavior. It has been reported that Ca(v)2.1 regulates neurotransmitter release and that Ca(2+) influx through Ca(v)2.1 decreases with aging. Age-related decline in cognitive function could be at least partly attributable to decreases in Ca(v)2.1-related neurotransmission. In this study to examine age-related cognitive alterations in heterozygous mice, we used Y-maze and delayed spatial win-shift eight-arm radial-maze tests, and 2- and 22-month-old mice. Although there was no difference between 2-month-old heterozygous and wild-type mice, 22-month-old heterozygous mice showed decreased memory formation versus 2-month-old heterozygous mice in both tests. Expression analysis in forebrain showed that total Ca(v)2.1alpha1 mRNA, including wild-type and mutant-type Ca(v)2.1alpha1 mRNA, in 2-month-old heterozygous mice was expressed at a level similar to that in 22-month-old heterozygous mice. However, wild-type Ca(v)2.1alpha1 mRNA was expressed at a lower level in 22-month-old mice than in 2-month-old mice, and mutant-type Ca(v)2.1alpha1 mRNA was expressed at a higher level in 22-month-old versus 2-month-old mice. Our results suggest that aged heterozygous mice show deficits in spatial learning due to Ca(v)2.1 channel dysfunction and that heterozygous mice may be a useful model for examining mechanisms underlying age-related cognitive dysfunction. |
| 巻・号 | 44(4) |
| ページ | 274-9 |
| 公開日 | 2009-4-1 |
| DOI | 10.1016/j.exger.2008.11.006 |
| PII | S0531-5565(08)00366-5 |
| PMID | 19073246 |
| MeSH | Aging / genetics Aging / physiology* Animals Ataxia / genetics Calcium Channels, N-Type / genetics Calcium Channels, N-Type / metabolism* Cognition Disorders / genetics Cognition Disorders / physiopathology* Maze Learning / physiology Mice Mice, Mutant Strains Reverse Transcriptase Polymerase Chain Reaction Spatial Behavior / physiology* Synaptic Transmission / genetics Synaptic Transmission / physiology* |
| IF | 3.376 |
| 引用数 | 13 |
| WOS 分野 | GERIATRICS & GERONTOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 実験動物マウス | RBRC00388 |