RRC ID 11781
Author Ikeda E, Morita R, Nakao K, Ishida K, Nakamura T, Takano-Yamamoto T, Ogawa M, Mizuno M, Kasugai S, Tsuji T.
Title Fully functional bioengineered tooth replacement as an organ replacement therapy.
Journal Proc Natl Acad Sci U S A
Abstract Current approaches to the development of regenerative therapies have been influenced by our understanding of embryonic development, stem cell biology, and tissue engineering technology. The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs which work in cooperation with surrounding tissues to replace organs that were lost or damaged as a result of disease, injury, or aging. Here, we report a successful fully functioning tooth replacement in an adult mouse achieved through the transplantation of bioengineered tooth germ into the alveolar bone in the lost tooth region. We propose this technology as a model for future organ replacement therapies. The bioengineered tooth, which was erupted and occluded, had the correct tooth structure, hardness of mineralized tissues for mastication, and response to noxious stimulations such as mechanical stress and pain in cooperation with other oral and maxillofacial tissues. This study represents a substantial advance and emphasizes the potential for bioengineered organ replacement in future regenerative therapies.
Volume 106(32)
Pages 13475-80
Published 2009-8-11
DOI 10.1073/pnas.0902944106
PII 0902944106
PMID 19666587
PMC PMC2720406
MeSH Animals Bioartificial Organs* Hardness Mastication / physiology Mice Mice, Inbred C57BL Neurons / physiology Pain / pathology Regenerative Medicine Stress, Mechanical Tissue Engineering* Tooth / physiology* Tooth / physiopathology Tooth Eruption / physiology*
IF 9.58
Times Cited 227
Mice C57BL/6-Tg(CAG-EGFP)C14-Y01-FM131Osb