| RRC ID |
11781
|
| 著者 |
Ikeda E, Morita R, Nakao K, Ishida K, Nakamura T, Takano-Yamamoto T, Ogawa M, Mizuno M, Kasugai S, Tsuji T.
|
| タイトル |
Fully functional bioengineered tooth replacement as an organ replacement therapy.
|
| ジャーナル |
Proc Natl Acad Sci U S A
|
| Abstract |
Current approaches to the development of regenerative therapies have been influenced by our understanding of embryonic development, stem cell biology, and tissue engineering technology. The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs which work in cooperation with surrounding tissues to replace organs that were lost or damaged as a result of disease, injury, or aging. Here, we report a successful fully functioning tooth replacement in an adult mouse achieved through the transplantation of bioengineered tooth germ into the alveolar bone in the lost tooth region. We propose this technology as a model for future organ replacement therapies. The bioengineered tooth, which was erupted and occluded, had the correct tooth structure, hardness of mineralized tissues for mastication, and response to noxious stimulations such as mechanical stress and pain in cooperation with other oral and maxillofacial tissues. This study represents a substantial advance and emphasizes the potential for bioengineered organ replacement in future regenerative therapies.
|
| 巻・号 |
106(32)
|
| ページ |
13475-80
|
| 公開日 |
2009-8-11
|
| DOI |
10.1073/pnas.0902944106
|
| PII |
0902944106
|
| PMID |
19666587
|
| PMC |
PMC2720406
|
| MeSH |
Animals
Bioartificial Organs*
Hardness
Mastication / physiology
Mice
Mice, Inbred C57BL
Neurons / physiology
Pain / pathology
Regenerative Medicine
Stress, Mechanical
Tissue Engineering*
Tooth / physiology*
Tooth / physiopathology
Tooth Eruption / physiology*
|
| IF |
9.412
|
| 引用数 |
227
|
|
WOS 分野
|
DENTISTRY, ORAL SURGERY & MEDICINE
|
| リソース情報 |
| 実験動物マウス |
RBRC00267 |
