RRC ID |
11787
|
著者 |
Osipova DV, Kulikov AV, Mekada K, Yoshiki A, Moshkin MP, Kotenkova EV, Popova NK.
|
タイトル |
Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice.
|
ジャーナル |
Genes Brain Behav
|
Abstract |
The neurotransmitter serotonin is implicated in the regulation of various forms of behavior, including aggression, sexual behavior and stress response. The rate of brain serotonin synthesis is determined by the activity of neuronal-specific enzyme tryptophan hydroxylase 2. The missense C1473G substitution in mouse tryptophan hydroxylase 2 gene has been shown to lower the enzyme activity and brain serotonin level. Here, the C1473G polymorphism was investigated in 84 common laboratory inbred strains, 39 inbred and semi-inbred strains derived from wild ancestors (mostly from Eurasia) and in 75 wild mice trapped in different locations in Russia and Armenia. Among all the classical inbred strains studied, only substrains of BALB/c, A and DBA, as well as the IITES/Nga and NZW/NSlc strains were homozygous for the 1473G allele. In contrast to laboratory strains, the 1473G allele was not present in any of the samples from wild and wild-derived mice, although the wild mice varied substantially in the C1477T neutral substitution closely linked to the C1473G polymorphism. According to these results, the frequency of the 1473G allele in natural populations does not exceed 0.5%, and the C1473G polymorphism is in fact a rare mutation that is possibly eliminated by the forces of natural selection.
|
巻・号 |
9(5)
|
ページ |
537-43
|
公開日 |
2010-7-1
|
DOI |
10.1111/j.1601-183X.2010.00586.x
|
PII |
GBB586
|
PMID |
20398061
|
MeSH |
Animals
Animals, Wild / genetics
Gene Frequency / genetics*
Genetic Variation*
Mice
Mice, Inbred Strains
Murinae / genetics*
Polymorphism, Single Nucleotide / genetics*
Tryptophan Hydroxylase / genetics*
|
IF |
3.397
|
引用数 |
15
|
WOS 分野
|
BEHAVIORAL SCIENCES
NEUROSCIENCES
|
リソース情報 |
実験動物マウス |
RBRC00197 |