RRC ID 11787
Author Osipova DV, Kulikov AV, Mekada K, Yoshiki A, Moshkin MP, Kotenkova EV, Popova NK.
Title Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice.
Journal Genes Brain Behav.
Abstract The neurotransmitter serotonin is implicated in the regulation of various forms of behavior, including aggression, sexual behavior and stress response. The rate of brain serotonin synthesis is determined by the activity of neuronal-specific enzyme tryptophan hydroxylase 2. The missense C1473G substitution in mouse tryptophan hydroxylase 2 gene has been shown to lower the enzyme activity and brain serotonin level. Here, the C1473G polymorphism was investigated in 84 common laboratory inbred strains, 39 inbred and semi-inbred strains derived from wild ancestors (mostly from Eurasia) and in 75 wild mice trapped in different locations in Russia and Armenia. Among all the classical inbred strains studied, only substrains of BALB/c, A and DBA, as well as the IITES/Nga and NZW/NSlc strains were homozygous for the 1473G allele. In contrast to laboratory strains, the 1473G allele was not present in any of the samples from wild and wild-derived mice, although the wild mice varied substantially in the C1477T neutral substitution closely linked to the C1473G polymorphism. According to these results, the frequency of the 1473G allele in natural populations does not exceed 0.5%, and the C1473G polymorphism is in fact a rare mutation that is possibly eliminated by the forces of natural selection.
Volume 9(5)
Pages 537-43
Published 2010-7
DOI 10.1111/j.1601-183X.2010.00586.x
PMID 20398061
MeSH Animals Animals, Wild / genetics Gene Frequency / genetics* Genetic Variation* Mice Mice, Inbred Strains Murinae / genetics* Polymorphism, Single Nucleotide / genetics* Tryptophan Hydroxylase / genetics*
IF 3.157
Times Cited 10