| RRC ID |
11837
|
| Author |
Chen CM, Wang HY, You LR, Shang RL, Liu FC.
|
| Title |
Expression analysis of an evolutionarily conserved metallophosphodiesterase gene, Mpped1, in the normal and beta-catenin-deficient malformed dorsal telencephalon.
|
| Journal |
Dev Dyn
|
| Abstract |
We report the expression of the mouse Mpped1 in the telencephalon through embryonic stages to adulthood. Using Northern blotting analysis and RNA in situ hybridization (ISH), our data show that Mpped1 is specifically expressed in the brain and is enriched in the cortical plate of the developing telencephalon. Postnatally, the expression of Mpped1 is reduced in the cerebral cortex relative to its levels in the embryonic dorsal telencephalon. Also, Mpped1 expression is sustained in the hippocampal CA1 region. Examination of the expression of Mpped1 and other cortical layer markers by ISH in a malformed beta-catenin null dorsal telencephalon show that the Mpped1-, Cux2-, and Rorbeta-expressing superficial cortical layers are reduced and form patchy patterns, and the Tbr-1-expressing deep-layer neurons are incorrectly located on superficial layers, indicative of a migration defect of cortical neurons in the absence of beta-catenin.
|
| Volume |
239(6)
|
| Pages |
1797-806
|
| Published |
2010-6-1
|
| DOI |
10.1002/dvdy.22293
|
| PMID |
20503375
|
| MeSH |
Animals
Blotting, Northern
CA1 Region, Hippocampal
Cerebral Cortex / embryology
Cerebral Cortex / metabolism
Embryo, Mammalian
Female
Genes
Mice
Mice, Congenic
Mice, Inbred C57BL
Mice, Inbred ICR
Mice, Transgenic
Neurons / metabolism
Pregnancy
Telencephalon / metabolism*
beta Catenin / genetics*
beta Catenin / metabolism
|
| IF |
3.275
|
| Times Cited |
6
|
|
WOS Category
|
ANATOMY & MORPHOLOGY
DEVELOPMENTAL BIOLOGY
|
| Resource |
| Mice |
RBRC01342 |
