論文 - 詳細
| RRC ID | 1189 |
|---|---|
| 著者 | Imaizumi T, Kumagai M, Sasaki N, Kurotaki H, Mori F, Seki M, Nishi N, Fujimoto K, Tanji K, Shibata T, Tamo W, Matsumiya T, Yoshida H, Cui XF, Takanashi S, Hanada K, Okumura K, Yagihashi S, Wakabayashi K, Nakamura T, Hirashima M, Satoh K. |
| タイトル | Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. |
| ジャーナル | J Leukoc Biol |
| Abstract |
Galectin-9 is a member of the galectin family and has been identified as an eosinophil chemoattractant produced by activated T lymphocytes. Vascular endothelial cells play an important role in the initial step of eosinophil recruitment and activation in immune and inflammatory responses. We have addressed the stimulation of galectin-9 expression in endothelial cells. Galectin-9 was detected in membrane and cytosolic fractions of human umbilical vein endothelial cells stimulated with interferon-gamma (IFN-gamma). IFN-gamma also enhanced the adhesion of human eosinophilic leukemia-1 cells to endothelial monolayers, and it was inhibited by the presence of lactose. Interleukin-4, which induces eotaxin expression, did not affect the expression of galectin-9. The in situ endothelium from patients with inflammatory diseases was found to express galectin-9. IFN-gamma-induced production of galectin-9 by endothelial cells may play an important role in immune responses by regulating interactions between the vascular wall and eosinophils. |
| 巻・号 | 72(3) |
| ページ | 486-91 |
| 公開日 | 2002-9-1 |
| PMID | 12223516 |
| MeSH | Autoimmune Diseases / metabolism Autoimmune Diseases / pathology Cell Adhesion / drug effects Cell Membrane / metabolism Cells, Cultured / drug effects Cells, Cultured / metabolism Chemokine CCL11 Chemokines, CC / biosynthesis Chemokines, CC / genetics Cytosol / metabolism Endothelium, Vascular / drug effects* Endothelium, Vascular / metabolism Eosinophils / cytology Galectins* Gene Expression Regulation / drug effects* Humans Hypereosinophilic Syndrome / pathology Interferon-gamma / pharmacology* Interleukin-4 / pharmacology Lactose / pharmacology Lectins / biosynthesis* Lectins / genetics Nasal Polyps / chemistry Recombinant Proteins Rhinitis, Allergic, Seasonal / metabolism Rhinitis, Allergic, Seasonal / pathology Sjogren's Syndrome / metabolism Sjogren's Syndrome / pathology Tumor Cells, Cultured / cytology Tumor Cells, Cultured / drug effects Umbilical Veins |
| IF | 3.757 |
| 引用数 | 119 |
| WOS 分野 | HEMATOLOGY IMMUNOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | EoL-1 cell(RCB0641) |