Reference - Detail
| RRC ID | 1192 |
|---|---|
| Author | Odashima M, Otaka M, Jin M, Konishi N, Sato T, Kato S, Matsuhashi T, Nakamura C, Watanabe S. |
| Title | Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine. |
| Journal | Dig Dis Sci |
| Abstract |
An antiulcer drug, zinc L-carnosine (polaprezinc), provides gastric mucosal protection against various irritants. In this study, we evaluated the effects of zinc L-carnosine on expression of 72-kDa heat shock protein (HSP72, stress inducible HSP70), which is known as an endogenous cytoprotectant in a wide variety of cells, including rat gastric mucosa in vitro and in vivo. Expression of HSP72 after exposure to zinc L-carnosine, zinc sulfate, or L-carnosine (1-300 microM) in rat gastric mucosal cells (RGM1) and intragastric administration of zinc L-carnosine, zinc sulfate (30 or 100 mg/kg) and L-carnosine (76 mg/kg) was investigated by western blotting and densitometric analysis. Exposure to zinc L-carnosine and zinc sulfate increased the expression of HSP72 significantly in RGM1 cells. Intragastric administration of zinc L-carnosine and zinc sulfate showed significant increment in HSP72 in rat gastric mucosa also in vivo. The ability to induce HSP72 is significantly higher in zinc L-carnosine compared with zinc sulfate based on molecular concentration in vivo. However, L-carnosine did not increase the expression of HSP72 in vitro and in vivo. Zinc derivatives, especially zinc L-carnosine, could be a strong HSP72 (chaperon) inducer, which has been known to enhance mucosal protective ability. |
| Volume | 47(12) |
| Pages | 2799-804 |
| Published | 2002-12-1 |
| DOI | 10.1023/a:1021029927386 |
| PMID | 12498304 |
| MeSH | Animals Carnosine / analogs & derivatives* Carnosine / pharmacology* Cells, Cultured Gastric Mucins / metabolism* Gastric Mucosa / metabolism* HSP72 Heat-Shock Proteins Heat-Shock Proteins / metabolism* Male Organometallic Compounds / pharmacology* Rats Rats, Sprague-Dawley Zinc Zinc Compounds Zinc Sulfate / pharmacology |
| IF | 2.751 |
| Times Cited | 60 |
| WOS Category | GASTROENTEROLOGY & HEPATOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RGM1(RCB0876) |