論文 - 詳細
| RRC ID | 11947 |
|---|---|
| 著者 | Inoue S, Noda S, Kashima K, Nakada K, Hayashi J, Miyoshi H. |
| タイトル | Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells. |
| ジャーナル | FEBS Lett |
| Abstract |
Mitochondrial energy production is involved in various cellular processes. Here we show that ATP content is significantly increased in lineage-restricted progenitor cells compared with hematopoietic stem and progenitor cells (HSPCs) or more differentiated cells. Transplantation analysis using a mouse model of mitochondrial disease revealed that mitochondrial respiration defects resulted in a significant decrease in the total number and repopulating activity of bone marrow cells, although the number of HSPCs increased. The proliferative activity of HSPCs and lineage-restricted progenitor cells was not impaired by reduction of ATP content and there seems to be no associated increase in reactive oxygen species levels and apoptosis. Our findings indicate that mitochondrial respiration defects modulate HSPC commitment/differentiation into lineage-restricted progenitor cells. |
| 巻・号 | 584(15) |
| ページ | 3402-9 |
| 公開日 | 2010-8-4 |
| DOI | 10.1016/j.febslet.2010.06.036 |
| PII | S0014-5793(10)00531-4 |
| PMID | 20600007 |
| MeSH | Adenosine Triphosphate / metabolism Animals Apoptosis Bone Marrow Cells / cytology Cell Cycle Cell Differentiation* Cell Lineage / genetics Cell Proliferation Cell Respiration DNA, Mitochondrial / metabolism Gene Expression Regulation, Developmental Hematopoiesis Hematopoietic Stem Cells / cytology* Hematopoietic Stem Cells / metabolism Mice Mitochondria / metabolism* Reactive Oxygen Species / metabolism |
| IF | 3.057 |
| 引用数 | 47 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 実験動物マウス | RBRC00144 |