Reference - Detail
| RRC ID | 11952 |
|---|---|
| Author | Nejigane S, Haramoto Y, Okuno M, Takahashi S, Asashima M. |
| Title | The transcriptional coactivators Yap and TAZ are expressed during early Xenopus development. |
| Journal | Int J Dev Biol |
| Abstract |
The Yap and TAZ genes encode highly conserved domains which bind various transcription factors. Yap and TAZ act as transcriptional coactivators to modulate transcriptional activity. The activities of Yap and TAZ are negatively regulated by Hippo signaling via direct phosphorylation. In this study, we describe the expression patterns of Yap and TAZ during the development of Xenopus tropicalis. The Xenopus tropicalis Yap (xtYap) and Xenopus tropicalis TAZ (xtTAZ) genes are expressed maternally. xtYap is widely expressed throughout embryogenesis, particularly in the facial connective tissues, branchial arch, midbrain-hindbrain boundary, otic vesicle, pronephros, notochord, hindgut and tailbud. xtTAZ expression occurs predominantly in the presomitic mesoderm, facial connective tissues, brain, branchial arch, trunk neural crest cells and migrating hypaxial myoblasts. In the muscle lineage, xtTAZ expression is transient and restricted to proliferating cells, the presomitic mesoderm and the edges of the hypaxial myoblasts, with no expression detected in mature muscle cells. These results provide insights into the functions of Yap and TAZ and their regulation by Hippo signaling during early development in Xenopus. |
| Volume | 55(1) |
| Pages | 121-6 |
| Published | 2011-1-1 |
| DOI | 10.1387/ijdb.103130sn |
| PII | 103130sn |
| PMID | 20979024 |
| MeSH | Amino Acid Sequence Animals Cloning, Molecular Gene Expression Profiling* Gene Expression Regulation, Developmental* In Situ Hybridization Molecular Sequence Data Phylogeny Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid Time Factors Trans-Activators / genetics* Xenopus / embryology Xenopus / genetics* Xenopus / growth & development Xenopus Proteins / classification Xenopus Proteins / genetics* |
| IF | 1.105 |
| Times Cited | 12 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
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| Total number of mentions | 0 |
| Resource | |
| Clawed frogs / Newts | |