論文 - 詳細
| RRC ID | 11965 |
|---|---|
| 著者 | Kuzuhara T, Iwai Y, Takahashi H, Hatakeyama D, Echigo N. |
| タイトル | Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase. |
| ジャーナル | PLoS Curr |
| Abstract |
The influenza A RNA polymerase possesses endonuclease activity to digest the host mRNA. Thus this endonuclease domain can be a target of anti-influenza A virus drug. Here we report that green tea catechins inhibit this viral endonuclease activity and that their galloyl group is important for their function. Docking simulations revealed that catechins with galloyl group fit well into the active pocket of the endonuclease domain to enable stable binding. Our results provide useful data that make it possible to refine and optimize catechin-based drug design more readily for stability. |
| 巻・号 | 1 |
| ページ | RRN1052 |
| 公開日 | 2009-10-13 |
| DOI | 10.1371/currents.rrn1052 |
| PII | k/-/-/1yn7909cwne80/2 |
| PMID | 20025206 |
| PMC | PMC2762814 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pBMSA-PA (RDB01971) |