RRC ID 12058
著者 Hirota K, Hanyu Y.
タイトル Method for identification of mutant glutathione S-transferases conferring enhanced resistance to the anti-cancer drug chlorambucil.
ジャーナル J Biosci Bioeng
Abstract We screened library of mutant glutathione S-transferases (GSTs) in Escherichia coli by successive treatments with anti-cancer drug chlorambucil and identified mutant GSTs that conferred enhanced resistance to host against chlorambucil compared with wild-type GST. This study provides a method to develop enzymes with improved efficiency of detoxification against cytotoxic substances.
巻・号 93(6)
ページ 618-21
公開日 2002-1-1
DOI 10.1016/s1389-1723(02)80248-1
PII S1389-1723(02)80248-1
PMID 16233260
IF 2.366
引用数 0
WOS 分野 BIOTECHNOLOGY & APPLIED MICROBIOLOGY FOOD SCIENCE & TECHNOLOGY
リソース情報
遺伝子材料 pGPi2 Human glutathione transferase-pi cDNA (RDB01393)