論文 - 詳細
| RRC ID | 12059 |
|---|---|
| 著者 | Nakamura T, Sasaki T, Fujimori M, Yazawa K, Kano Y, Amano J, Taniguchi S. |
| タイトル | Cloned cytosine deaminase gene expression of Bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Bifidobacterium longum is a nonpathogenic anaerobic bacterium among normal bacterial flora. Recently, it was reported that B. longum accumulated in hypoxic solid tumors. The gene of interest was expressed in transfected B. longum by the shuttle vector pBLES100 in solid tumors. In this report, we constructed pBLES100-S-eCD, which included the cytosine deaminase gene. We confirmed by western blotting that transfected B. longum produced cytosine deaminase. In addition, transfected B. longum produced cytosine deaminase that converted 5-fluorocytosine into 5-fluorouracil. B. longum could be useful for enzyme/pro-drug therapy of hypoxic solid tumors. |
| 巻・号 | 66(11) |
| ページ | 2362-6 |
| 公開日 | 2002-11-1 |
| DOI | 10.1271/bbb.66.2362 |
| PMID | 12506973 |
| MeSH | Antimetabolites, Antineoplastic / pharmacokinetics* Antimetabolites, Antineoplastic / therapeutic use Bifidobacterium / enzymology* Bifidobacterium / genetics* Bifidobacterium / metabolism Blotting, Western Cloning, Molecular Cytosine Deaminase Flucytosine / pharmacokinetics* Flucytosine / therapeutic use Fluorouracil / pharmacokinetics* Fluorouracil / therapeutic use Gene Expression Genetic Therapy / methods* Genetic Vectors / genetics Hypoxia / physiopathology Neoplasms / drug therapy Nucleoside Deaminases / genetics* Nucleoside Deaminases / metabolism* Prodrugs / pharmacokinetics* Prodrugs / therapeutic use Transfection Transformation, Bacterial |
| IF | 1.516 |
| 引用数 | 49 |
| WOS 分野 | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 19 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pAxCACD pAdex1CACD (RDB1591) |