RRC ID 12102
Author Lyons DA, Naylor SG, Scholze A, Talbot WS.
Title Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons.
Journal Nat. Genet.
Abstract The kinesin motor protein Kif1b has previously been implicated in the axonal transport of mitochondria and synaptic vesicles. More recently, KIF1B has been associated with susceptibility to multiple sclerosis (MS). Here we show that Kif1b is required for the localization of mbp (myelin basic protein) mRNA to processes of myelinating oligodendrocytes in zebrafish. We observe the ectopic appearance of myelin-like membrane in kif1b mutants, coincident with the ectopic localization of myelin proteins in kif1b mutant oligodendrocyte cell bodies. These observations suggest that oligodendrocytes localize certain mRNA molecules, namely those encoding small basic proteins such as MBP, to prevent aberrant effects of these proteins elsewhere in the cell. We also find that Kif1b is required for outgrowth of some of the longest axons in the peripheral and central nervous systems. Our data demonstrate previously unknown functions of kif1b in vivo and provide insights into its possible roles in MS.
Volume 41(7)
Pages 854-8
Published 2009-7
DOI 10.1038/ng.376
PII ng.376
PMID 19503091
PMC PMC2702462
MeSH Animals Axons / metabolism* Humans Kinesin / genetics Kinesin / metabolism* Molecular Sequence Data Multiple Sclerosis Myelin Basic Protein / genetics Myelin Basic Protein / metabolism Myelin Sheath / metabolism* Oligodendroglia / metabolism* Zebrafish Zebrafish Proteins / genetics Zebrafish Proteins / metabolism*
IF 27.959
Times Cited 84
WOS Category GENETICS & HEREDITY
Resource
Zebrafish rw0130a(Tg (Huc:Kaede))?