論文 - 詳細
| RRC ID | 12102 |
|---|---|
| 著者 | Lyons DA, Naylor SG, Scholze A, Talbot WS. |
| タイトル | Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons. |
| ジャーナル | Nat Genet |
| Abstract |
The kinesin motor protein Kif1b has previously been implicated in the axonal transport of mitochondria and synaptic vesicles. More recently, KIF1B has been associated with susceptibility to multiple sclerosis (MS). Here we show that Kif1b is required for the localization of mbp (myelin basic protein) mRNA to processes of myelinating oligodendrocytes in zebrafish. We observe the ectopic appearance of myelin-like membrane in kif1b mutants, coincident with the ectopic localization of myelin proteins in kif1b mutant oligodendrocyte cell bodies. These observations suggest that oligodendrocytes localize certain mRNA molecules, namely those encoding small basic proteins such as MBP, to prevent aberrant effects of these proteins elsewhere in the cell. We also find that Kif1b is required for outgrowth of some of the longest axons in the peripheral and central nervous systems. Our data demonstrate previously unknown functions of kif1b in vivo and provide insights into its possible roles in MS. |
| 巻・号 | 41(7) |
| ページ | 854-8 |
| 公開日 | 2009-7-1 |
| DOI | 10.1038/ng.376 |
| PII | ng.376 |
| PMID | 19503091 |
| PMC | PMC2702462 |
| MeSH | Animals Axons / metabolism* Humans Kinesins / genetics Kinesins / metabolism* Molecular Sequence Data Multiple Sclerosis Myelin Basic Protein / genetics Myelin Basic Protein / metabolism Myelin Sheath / metabolism* Oligodendroglia / metabolism* Zebrafish Zebrafish Proteins / genetics Zebrafish Proteins / metabolism* |
| IF | 27.605 |
| 引用数 | 108 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | rw0130a(Tg (Huc:Kaede))? |