RRC ID 12165
Author Takekoshi K, Ishii K, Kawakami Y, Isobe K, Nakai T.
Title kappa-Opioid inhibits catecholamine biosynthesis in PC12 rat pheochromocytoma cell.
Journal FEBS Lett.
Abstract /=100 nM) significantly inhibited the nicotine-induced increase of both the TH protein level and intracellular catecholamine levels. These results indicate that the anti-cholinergic actions of kappa-opioid can be explained partially by its inhibition of both TH enzyme activity and TH synthesis, through suppression of the cAMP/protein kinase A pathway. It would also appear that the PTX-sensitive G-protein mediates the inhibitory effect of this pathway, at least in part.
Volume 477(3)
Pages 273-7
Published 2000-7-21
PII S0014-5793(00)01789-0
PMID 10908734
MeSH Animals Benzeneacetamides* Catecholamines / antagonists & inhibitors* Catecholamines / biosynthesis Cyclic AMP / biosynthesis Nicotine / pharmacology Opioid Peptides / pharmacology* PC12 Cells Pyrrolidines / pharmacology RNA, Messenger / genetics Rats Receptors, Opioid, kappa / agonists Tyrosine 3-Monooxygenase / antagonists & inhibitors Tyrosine 3-Monooxygenase / genetics
IF 2.999
Times Cited 17
WOS Category BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
Resource
DNA material pHTH1 Human tyrosine hydroxylase type I cDNA (RDB01269)