Reference - Detail
| RRC ID | 12165 |
|---|---|
| Author | Takekoshi K, Ishii K, Kawakami Y, Isobe K, Nakai T. |
| Title | kappa-Opioid inhibits catecholamine biosynthesis in PC12 rat pheochromocytoma cell. |
| Journal | FEBS Lett. |
| Abstract |
/=100 nM) significantly inhibited the nicotine-induced increase of both the TH protein level and intracellular catecholamine levels. These results indicate that the anti-cholinergic actions of kappa-opioid can be explained partially by its inhibition of both TH enzyme activity and TH synthesis, through suppression of the cAMP/protein kinase A pathway. It would also appear that the PTX-sensitive G-protein mediates the inhibitory effect of this pathway, at least in part. |
| Volume | 477(3) |
| Pages | 273-7 |
| Published | 2000-7-21 |
| PII | S0014-5793(00)01789-0 |
| PMID | 10908734 |
| MeSH | Animals Benzeneacetamides* Catecholamines / antagonists & inhibitors* Catecholamines / biosynthesis Cyclic AMP / biosynthesis Nicotine / pharmacology Opioid Peptides / pharmacology* PC12 Cells Pyrrolidines / pharmacology RNA, Messenger / genetics Rats Receptors, Opioid, kappa / agonists Tyrosine 3-Monooxygenase / antagonists & inhibitors Tyrosine 3-Monooxygenase / genetics |
| IF | 2.999 |
| Times Cited | 17 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| DNA material | pHTH1 Human tyrosine hydroxylase type I cDNA (RDB01269) |