Reference - Detail
RRC ID | 12165 |
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Author | Takekoshi K, Ishii K, Kawakami Y, Isobe K, Nakai T. |
Title | kappa-Opioid inhibits catecholamine biosynthesis in PC12 rat pheochromocytoma cell. |
Journal | FEBS Lett. |
Abstract |
/=100 nM) significantly inhibited the nicotine-induced increase of both the TH protein level and intracellular catecholamine levels. These results indicate that the anti-cholinergic actions of kappa-opioid can be explained partially by its inhibition of both TH enzyme activity and TH synthesis, through suppression of the cAMP/protein kinase A pathway. It would also appear that the PTX-sensitive G-protein mediates the inhibitory effect of this pathway, at least in part. |
Volume | 477(3) |
Pages | 273-7 |
Published | 2000-7-21 |
PII | S0014-5793(00)01789-0 |
PMID | 10908734 |
MeSH | Animals Benzeneacetamides* Catecholamines / antagonists & inhibitors* Catecholamines / biosynthesis Cyclic AMP / biosynthesis Nicotine / pharmacology Opioid Peptides / pharmacology* PC12 Cells Pyrrolidines / pharmacology RNA, Messenger / genetics Rats Receptors, Opioid, kappa / agonists Tyrosine 3-Monooxygenase / antagonists & inhibitors Tyrosine 3-Monooxygenase / genetics |
IF | 2.999 |
Times Cited | 17 |
WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
Resource | |
DNA material | pHTH1 Human tyrosine hydroxylase type I cDNA (RDB01269) |