Reference - Detail
|Author||Takekoshi K, Ishii K, Kawakami Y, Isobe K, Nakai T.|
|Title||kappa-Opioid inhibits catecholamine biosynthesis in PC12 rat pheochromocytoma cell.|
/=100 nM) significantly inhibited the nicotine-induced increase of both the TH protein level and intracellular catecholamine levels. These results indicate that the anti-cholinergic actions of kappa-opioid can be explained partially by its inhibition of both TH enzyme activity and TH synthesis, through suppression of the cAMP/protein kinase A pathway. It would also appear that the PTX-sensitive G-protein mediates the inhibitory effect of this pathway, at least in part.
|MeSH||Animals Benzeneacetamides* Catecholamines / antagonists & inhibitors* Catecholamines / biosynthesis Cyclic AMP / biosynthesis Nicotine / pharmacology Opioid Peptides / pharmacology* PC12 Cells Pyrrolidines / pharmacology RNA, Messenger / genetics Rats Receptors, Opioid, kappa / agonists Tyrosine 3-Monooxygenase / antagonists & inhibitors Tyrosine 3-Monooxygenase / genetics|
|WOS Category||BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY|
|DNA material||pHTH1 Human tyrosine hydroxylase type I cDNA (RDB01269)|