Reference - Detail
| RRC ID | 12179 |
|---|---|
| Author | Miyazaki M, Takemura N, Watanabe S, Hata N, Misawa Y, Okuyama H. |
| Title | Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-beta, fibronectin and renin. |
| Journal | Biochim Biophys Acta |
| Abstract |
We have noted that n-3 fatty acid-rich oils, such as fish oil, perilla oil and flaxseed oil as well as ethyl docosahexaenoate (DHA) prolonged the survival time of stroke-prone spontaneously hypertensive rats (SHRSP) rats by approximately 10% as compared with linoleate (n-6)-rich safflower oil. Rapeseed oil with a relatively low n-6/n-3 ratio unusually shortened the survival time by approximately 40%, suggesting the presence of minor components unfavorable to SHRSP rats. This study examined the effects of dietary oils and DHA on renal injury and gene expression related to renal injury in SHRSP rats. Rats fed rapeseed oil- and safflower oil-supplemented diets developed more severe proteinuria than those fed soybean oil-supplemented diet used as a control, but there were no significant differences in blood pressure. In contrast, the DHA-supplemented diet inhibited the development of proteinuria and suppressed hypertension. The mRNA levels for renal TGF-beta, fibronectin and renin were higher in the rapeseed oil and safflower oil groups after 9 weeks of feeding of the experimental diet than in the soybean oil and DHA groups. The fatty acid composition of kidney phospholipids was markedly affected by these diets. These results indicate that the renal injury observed in the groups fed safflower oil with a high n-6/n-3 ratio and rapeseed oil with presumed minor components is accompanied by increased expression of the TGF-beta, renin and fibronectin genes, and that dietary DHA suppresses renal injury and gene expression as compared with soybean oil. |
| Volume | 1483(1) |
| Pages | 101-10 |
| Published | 2000-1-3 |
| DOI | 10.1016/s1388-1981(99)00180-8 |
| PII | S1388-1981(99)00180-8 |
| PMID | 10601699 |
| MeSH | Animals Blood Pressure Dietary Fats / pharmacology* Dietary Fats, Unsaturated / pharmacology* Docosahexaenoic Acids / pharmacology* Fatty Acids / analysis Fatty Acids, Monounsaturated Fibronectins / genetics Fibronectins / metabolism Gene Expression Heart Rate Kidney / drug effects* Kidney / physiopathology Phospholipids / metabolism Plant Oils / pharmacology RNA, Messenger / metabolism Rapeseed Oil Rats Rats, Inbred SHR Renin / genetics Renin / metabolism Safflower Oil / pharmacology Soybean Oil / pharmacology Stroke / physiopathology* Time Factors Transforming Growth Factor beta / genetics Transforming Growth Factor beta / metabolism |
| IF | 3.411 |
| Times Cited | 23 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| DNA material | pTGF-11 (RDB01195) |