論文 - 詳細
| RRC ID | 12212 |
|---|---|
| 著者 | Ohashi T, Sato S, Yoshiki A, Kusakabe M. |
| タイトル | TSC-36 (follistatin-related polypeptide) gene expression in estrogen receptor positive osteoblastic cell line, CDO7F. |
| ジャーナル | Calcif Tissue Int |
| Abstract |
Using an osteoblastic cell line (CDO7F) that was selected as an estrogen receptor positive cell by immunocytochemical detection and reverse transcription-polymerase chain reaction (RT-PCR) subtractive cDNA cloning using oligo(dT)30-Latex and PCR was performed to isolate a gene that is induced by estrogen. A cDNA clone was isolated and its nucleotide sequence identified it as TSC 36, previously called follistatin-related polypeptide. Northern blot analysis showed that the TSC-36 gene expression was certainly upregulated by estrogen. Tamoxifen also upregulated this gene expression. These findings indicate that TSC-36 may be one of the estrogen-regulated genes in osteoblastic cells. |
| 巻・号 | 61(5) |
| ページ | 400-3 |
| 公開日 | 1997-11-1 |
| DOI | 10.1007/s002239900355 |
| PMID | 9351882 |
| MeSH | Animals Cell Line Cloning, Molecular DNA, Complementary / genetics Estrogen Antagonists / pharmacology Estrogens / pharmacology Follistatin-Related Proteins Gene Expression Regulation / genetics* Glycoproteins / biosynthesis Glycoproteins / genetics* Mice Osteoblasts / drug effects* Osteoblasts / metabolism Receptors, Estrogen / genetics* Receptors, Estrogen / metabolism Tamoxifen / pharmacology Up-Regulation |
| IF | 3.423 |
| 引用数 | 10 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM |
| リソース情報 | |
| 遺伝子材料 | pTGF-11 (RDB01195) |