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Species Resource Title
DNA material pCAG-HIVgp (RDB04394) , CS-RfA-CG (RDB04390) , pCMV-VSV-G-RSV-Rev (RDB04393) Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1.
Human and Animal Cells HCT116(RCB2979) , COLO205(RCB2127) SHARPIN is a novel gene of colorectal cancer that promotes tumor growth potentially via inhibition of p53 expression.
Human and Animal Cells HUDEP-2(RCB4557) Upregulation of miR‑6747‑3p affects red blood cell lineage development and induces fetal hemoglobin expression by targeting BCL11A in β‑thalassemia.
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
Human and Animal Cells 293T(RCB2202) miR-709 exerts an angiogenic effect through a FGF2 upregulation induced by a GSK3B downregulation.
General Microbes JCM1134 Long Short-Term Memory-Based Multiomics Reveal Lactobacillus casei-Derived Postbiotics Inhibiting Lipids Digestion via Mediating the Upregulation of α-Helices in Lipase.
DNA material CSII-CMV-MCS-IRES2-Bsd (RDB04385) , CSII-BNRF1-HA (RDB20444) Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation.
Human and Animal Cells A549(RCB0098) Copper in airborne fine particulate matter (PM2.5) from urban sites causes the upregulation of pro-inflammatory cytokine IL-8 in human lung epithelial A549 cells.
Human and Animal Cells HSC-3(RCB1975) , HSC-4(RCB1902) Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation.
Pathogenic eukaryotic microorganisms Leishmania donovani Upregulation of ATP6V0D2 benefits intracellular survival of Leishmania donovani in erythrocytes-engulfing macrophages
Human and Animal Cells RMS-YM(RCB1695) Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth.
Human and Animal Cells HCE-T(RCB1384) JNK MAPK signaling contributes in vivo to injury-induced corneal epithelial migration.
DNA material pKM2L-phBMP6 (RDB05474) Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation.
Human and Animal Cells HUDEP-2(RCB4557) A natural DNMT1 mutation elevates the fetal hemoglobin level via epigenetic derepression of the γ-globin gene in β-thalassemia.
Human and Animal Cells Saos-2(RCB0428) , HOS(RCB0992) Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells.
Human and Animal Cells Hep G2(RCB1648) , HuH-7(RCB1942) Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility.
C.elegans tm1155 , tm1978 The transcription factor HLH-26 controls probiotic-mediated protection against intestinal infection through up-regulation of the Wnt/BAR-1 pathway.
C.elegans tm6722 , tm6526 Effector and regulator: Diverse functions of C. elegans C-type lectin-like domain proteins.
Human and Animal Cells A549 Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells.
Pathogenic eukaryotic microorganisms Leishmania donovani Ld003 Leishmania infection-induced multinucleated giant cell formation via upregulation of ATP6V0D2 expression.