RRC ID 12218
Author Murakami T, Yamashita T, Iida M, Kuwajima M, Shima K.
Title A short form of leptin receptor performs signal transduction.
Journal Biochem Biophys Res Commun
Abstract The obese (ob) gene product, leptin, a peptide hormone, which is synthesized in adipocytes, is a satiety factor and is involved in the control of body weight via the regulation of energy homeostasis. Several alternate spliced isoforms (a-e, as well as others) of the leptin receptor (OBR) have been cloned, all of which, except for OBRe (soluble form), contain a single transmembrane domain. They share the same extracellular domain, with homology to the class I cytokine receptor family. The OBRb, which has longest cytoplasmic domain, is expressed in high levels in the hypothalamus and is thought to be the only isoform capable of signal transmission. Herein, we report the mRNA expression of immediate early genes, c-fos, c-jun and jun-B, which are induced by leptin addition, not only in CHO cells expressing the OBRb, but also in cells expressing one of the short form receptors, OBRa.
Volume 231(1)
Pages 26-9
Published 1997-2-3
DOI 10.1006/bbrc.1996.6030
PII S0006-291X(96)96030-1
PMID 9070213
MeSH Animals CHO Cells Carrier Proteins / chemistry Carrier Proteins / genetics Carrier Proteins / metabolism* Cricetinae Gene Expression Regulation* Genes, Immediate-Early* Genes, fos Genes, jun Leptin Proteins / metabolism Proteins / pharmacology* RNA, Messenger / genetics RNA, Messenger / metabolism Rats Receptors, Cell Surface* Receptors, Cytokine / chemistry Receptors, Cytokine / genetics Receptors, Cytokine / metabolism* Receptors, Leptin Recombinant Proteins / metabolism Recombinant Proteins / pharmacology Signal Transduction* Transfection
IF 2.705
Times Cited 176
DNA material 465.20 Mouse JunB (RDB01298)