論文 - 詳細
| RRC ID | 12357 |
|---|---|
| 著者 | Sawada M, Kaneko N, Inada H, Wake H, Kato Y, Yanagawa Y, Kobayashi K, Nemoto T, Nabekura J, Sawamoto K. |
| タイトル | Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb. |
| ジャーナル | J Neurosci |
| Abstract |
Throughout life, new neurons are added and old ones eliminated in the adult mouse olfactory bulb. Previous studies suggested that olfactory experience controls the process by which new neurons are integrated into mature circuits. Here we report novel olfactory-experience-dependent mechanisms of neuronal turnover. Using two-photon laser-scanning microscopy and sensory manipulations in adult live mice, we found that the neuronal turnover was dynamically controlled by olfactory input in a neuronal subtype-specific manner. Olfactory input enhanced this turnover, which was characterized by the reiterated use of the same positions in the glomeruli by new neurons. Our results suggest that olfactory-experience-dependent modification of neuronal turnover confers structural plasticity and stability on the olfactory bulb. |
| 巻・号 | 31(32) |
| ページ | 11587-96 |
| 公開日 | 2011-8-10 |
| DOI | 10.1523/JNEUROSCI.0614-11.2011 |
| PII | 31/32/11587 |
| PMID | 21832189 |
| PMC | PMC6623130 |
| MeSH | Age Factors Animals Male Mice Mice, Inbred C57BL Mice, Transgenic Neurogenesis / physiology* Neurons / cytology Neurons / physiology Odorants* Olfactory Bulb / cytology Olfactory Bulb / physiology* Olfactory Receptor Neurons / cytology Olfactory Receptor Neurons / physiology* Sensory Deprivation / physiology* Smell / physiology* |
| IF | 5.674 |
| 引用数 | 48 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02095 |