RRC ID 124
Author Zhang GH, Min SS, Lee KS, Back SK, Yoon SJ, Yoon YW, Kim YI, Na HS, Hong SK, Han HC.
Title Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats.
Journal Anesth. Analg.
Abstract To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats. Injection of ketamine (0.2 mg and 1 mg) or memantine (0.1 mg, 0.2 mg, and 1 mg) into the knee joint, but not the abdominal cavity, immediately before carrageenan injection (2%, 40 microL) significantly prevented pain-related behavior. The intraarticular injection of ketamine (1 mg) or memantine (0.2 mg) also suppressed c-Fos expression in the laminae I-II and laminae V-VI at the L3-4 spinal level. Subsequent statistical analyses revealed that the degree of the spinal c-Fos expression was correlated with the extent of the pain-related behavior. These results suggest that peripheral administration of NMDA receptor antagonists has prophylactic analgesic effects in arthritic pain, which might be associated with the decrease of central nociceptive signaling. Because ketamine and memantine are currently used in humans and considered clinically safe, they may have therapeutic value in the treatment of joint pain.
Volume 99(1)
Pages 152-8
Published 2004-7
PMID 15281522
MeSH Animals Arthritis, Experimental / chemically induced Arthritis, Experimental / complications* Behavior, Animal / drug effects Body Weight / drug effects Carrageenan Excitatory Amino Acid Antagonists / administration & dosage Excitatory Amino Acid Antagonists / therapeutic use* Gene Expression / drug effects* Genes, fos / drug effects* Immunohistochemistry Injections, Intra-Articular Ketamine / administration & dosage Ketamine / therapeutic use* Male Memantine / administration & dosage Memantine / therapeutic use* Pain / etiology Pain / prevention & control* Posterior Horn Cells / drug effects Posterior Horn Cells / metabolism Rats Rats, Sprague-Dawley Signal Transduction / drug effects Weight-Bearing / physiology
IF 3.463
Times Cited 18