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  • Search Condition : Filter (MeSH = Signal Transduction / drug effects)
Species Resource
DNA material pHSP90 (RDB01127) Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox.
DNA material AxCALacZ (RDB1745) Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy.
Yeast HM123 Valproic acid affects membrane trafficking and cell-wall integrity in fission yeast.
DNA material pSTAT RE-TK hRluc(F) (RDB05616) , pISRE-TK hRluc(F) (RDB05610) , pGAS RE-TK hRluc(F) (RDB05624). Chondromodulin-1 directly suppresses growth of human cancer cells.
DNA material pAxCAwt (RDB1678) Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function.
DNA material Mouse E-cadherin full length cDNA (RDB01184) Design of the artificial acellular feeder layer for the efficient propagation of mouse embryonic stem cells.
C.elegans tm445 , tm501 Caenorhabditis elegans integrates the signals of butanone and food to enhance chemotaxis to butanone.
Arabidopsis / Cultured plant cells, genes rpc00008  Modulation of defense signal transduction by flagellin-induced WRKY41 transcription factor in Arabidopsis thaliana.
C.elegans tm1325 An antidepressant that extends lifespan in adult Caenorhabditis elegans.
C.elegans tm1996 Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans.
C.elegans tm331 Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity.
C.elegans tm748 Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3.
Human embryonic stem cells KhES-1 , KhES-3 Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling.
Mice C57BL/6-Grm2 tm Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists.
Mice EpoR(-/-) ::HG1-EpoR mouse Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-κB-inducible immune pathways.
DNA material pCMX-N/RBP-J (R218H) (RDB03022) Regulation of non-classical FGF1 release and FGF-dependent cell transformation by CBF1-mediated notch signaling.
Mice IRF-3遺伝子欠損マウス Multiple preconditioning paradigms converge on interferon regulatory factor-dependent signaling to promote tolerance to ischemic brain injury.
Arabidopsis / Cultured plant cells, genes rpc00012 Discovery of a small peptide from combinatorial libraries that can activate the plant immune system by a jasmonic acid signaling pathway.
Yeast ? Fission yeast Rad26ATRIP delays spindle-pole-body separation following interphase microtubule damage.
Mice TgN(deGFP)18Imeg Reduced oxygen concentration enhances conversion of embryonic stem cells to epiblast stem cells.