論文 - 詳細
| RRC ID | 12435 |
|---|---|
| 著者 | Asaka-Amano Y, Takiguchi Y, Yatomi M, Kurosu K, Kasahara Y, Tanabe N, Tatsumi K, Kuriyama T. |
| タイトル | Effect of treatment schedule on the interaction of Cisplatin and radiation in human lung cancer cells. |
| ジャーナル | Radiat Res |
| Abstract |
This study was designed to determine the effects of the treatment schedule on the interaction between cisplatin and radiation. Cells of a human squamous cell lung cancer cell line were treated with cisplatin and radiation using three treatment protocols: 1-h exposure to cisplatin immediately followed by irradiation (A), 4-day continuous exposure to cisplatin immediately followed by irradiation (B), and 1-h exposure to cisplatin followed by irradiation after a 4-day interval (C). The interactions were assessed by isobologram, cell cycle distribution and apoptosis. The combination resulted in a additive effect in every protocol. Cell cycle accumulation at G(2)/M phase before irradiation was observed in Protocols B and C, whereas no cell cycle shift in the limited time course was noted in Protocol A. Although a 4-day continuous exposure to cisplatin and a 1-h exposure to cisplatin followed by a 4-day interval before irradiation caused significantly increased apoptosis, an additional increase in apoptosis after irradiation was not observed in Protocols B and C, whereas Protocol A showed an additional increase. Despite a cell cycle shift favoring radiation sensitivity, the drug-radiation interactions in Protocols B and C were additive, possibly because of negative effects including induction of a durable G(2)/M-phase arrest and suppression of apoptosis by cisplatin. |
| 巻・号 | 167(6) |
| ページ | 637-44 |
| 公開日 | 2007-6-1 |
| DOI | 10.1667/RR0739.1 |
| PII | RR0739 |
| PMID | 17523845 |
| MeSH | Antineoplastic Agents / administration & dosage Apoptosis / drug effects Apoptosis / radiation effects Carcinoma, Squamous Cell / pathology* Carcinoma, Squamous Cell / therapy* Cell Cycle / drug effects Cell Cycle / radiation effects Cell Line, Tumor Cisplatin / administration & dosage* Dose Fractionation, Radiation Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drug Administration Schedule Humans Lung Neoplasms / pathology* Lung Neoplasms / therapy* Radiation Dosage Radiation Tolerance / drug effects* Radiation-Sensitizing Agents / administration & dosage Radiotherapy, Adjuvant |
| IF | 2.657 |
| 引用数 | 4 |
| WOS 分野 | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BIOLOGY BIOPHYSICS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | RERF-LC-AI(RCB0444) |