論文 - 詳細
| RRC ID | 12477 |
|---|---|
| 著者 | Takegawa K, Tohda H, Sasaki M, Idiris A, Ohashi T, Mukaiyama H, Giga-Hama Y, Kumagai H. |
| タイトル | Production of heterologous proteins using the fission-yeast (Schizosaccharomyces pombe) expression system. |
| ジャーナル | Biotechnol Appl Biochem |
| Abstract |
The fission yeast Schizosaccharomyces pombe is a particularly useful model for studying the function and regulation of genes from higher eukaryotes. The genome of Sc. pombe has been sequenced, and DNA microarray, proteome and transcriptome analyses have been carried out. Among the well-characterized yeast species, Sc. pombe is considered an attractive host for the production of heterologous proteins. Expression vectors for high-level expression in Sc. pombe have been developed and many foreign proteins have been successfully expressed. However, further improvements in the protein-expressing host systems are still required for the production of heterologous proteins involved in post-translational modification, metabolism and intracellular trafficking. This minireview focuses on recent advances in heterologous protein production by use of engineered fission-yeast strains. |
| 巻・号 | 53(Pt 4) |
| ページ | 227-35 |
| 公開日 | 2009-6-22 |
| DOI | 10.1042/BA20090048 |
| PII | BA20090048 |
| PMID | 19531030 |
| MeSH | Genetic Engineering Genetic Vectors / genetics Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Recombinant Proteins / biosynthesis* Recombinant Proteins / genetics* Schizosaccharomyces / genetics* Schizosaccharomyces / metabolism |
| IF | 1.638 |
| 引用数 | 42 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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