| RRC ID |
124
|
| 著者 |
Zhang GH, Min SS, Lee KS, Back SK, Yoon SJ, Yoon YW, Kim YI, Na HS, Hong SK, Han HC.
|
| タイトル |
Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats.
|
| ジャーナル |
Anesth Analg
|
| Abstract |
To determine whether intraarticular pretreatment with N-methyl-D-aspartic (NMDA) receptor antagonist ketamine or memantine currently used in humans has prophylactic analgesia in arthritic pain, we examined the effects of their intraarticular injection before carrageenan injection into the knee joint on pain-related behavior and spinal c-Fos expression in rats. Injection of ketamine (0.2 mg and 1 mg) or memantine (0.1 mg, 0.2 mg, and 1 mg) into the knee joint, but not the abdominal cavity, immediately before carrageenan injection (2%, 40 microL) significantly prevented pain-related behavior. The intraarticular injection of ketamine (1 mg) or memantine (0.2 mg) also suppressed c-Fos expression in the laminae I-II and laminae V-VI at the L3-4 spinal level. Subsequent statistical analyses revealed that the degree of the spinal c-Fos expression was correlated with the extent of the pain-related behavior. These results suggest that peripheral administration of NMDA receptor antagonists has prophylactic analgesic effects in arthritic pain, which might be associated with the decrease of central nociceptive signaling. Because ketamine and memantine are currently used in humans and considered clinically safe, they may have therapeutic value in the treatment of joint pain.
|
| 巻・号 |
99(1)
|
| ページ |
152-158
|
| 公開日 |
2004-7-1
|
| DOI |
10.1213/01.ANE.0000117141.76392.65
|
| PII |
00000539-200407000-00032
|
| PMID |
15281522
|
| MeSH |
Animals
Arthritis, Experimental / chemically induced
Arthritis, Experimental / complications*
Behavior, Animal / drug effects
Body Weight / drug effects
Carrageenan
Excitatory Amino Acid Antagonists / administration & dosage
Excitatory Amino Acid Antagonists / therapeutic use*
Gene Expression / drug effects*
Genes, fos / drug effects*
Immunohistochemistry
Injections, Intra-Articular
Ketamine / administration & dosage
Ketamine / therapeutic use*
Male
Memantine / administration & dosage
Memantine / therapeutic use*
Pain / etiology
Pain / prevention & control*
Posterior Horn Cells / drug effects
Posterior Horn Cells / metabolism
Rats
Rats, Sprague-Dawley
Signal Transduction / drug effects
Weight-Bearing / physiology
|
| IF |
4.305
|
| 引用数 |
22
|
|
WOS 分野
|
ANESTHESIOLOGY
|
| リソース情報 |
| ラット |
|
