論文 - 詳細
| RRC ID | 1258 |
|---|---|
| 著者 | Iwata K, Ogata S, Okumura K, Taguchi H. |
| タイトル | Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Water-soluble vitamin, niacin, and its related compounds were examined for their differentiation-inducing activity in human promyelocytic leukemia cells (HL-60). Among the compounds, which inhibited cell proliferation measured by MTT assay, isonicotinic acid, nicotinamide N-oxide, and nicotinamide induced NBT reducing activity. HL-60 cells were differentiated into granulocyte-like cells by these compounds, judging from morphological changes and loss of nonspecific esterase activity. The differentiation-inducing activity of water-soluble vitamin and its related compounds suggest that these compounds may be applicable for medical use. |
| 巻・号 | 67(5) |
| ページ | 1132-5 |
| 公開日 | 2003-5-1 |
| DOI | 10.1271/bbb.67.1132 |
| PMID | 12834294 |
| MeSH | Cell Differentiation / drug effects Cell Division / drug effects Cell Survival / drug effects HL-60 Cells Humans Isonicotinic Acids / pharmacology L-Lactate Dehydrogenase / metabolism Niacin / analogs & derivatives* Niacin / pharmacology* |
| IF | 1.516 |
| 引用数 | 21 |
| WOS 分野 | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |