論文 - 詳細
| RRC ID | 12594 |
|---|---|
| 著者 | Fujita A. |
| タイトル | ADP-ribosylation factor arf6p may function as a molecular switch of new end take off in fission yeast. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Small GTPases act as molecular switches in a wide variety of cellular processes. In fission yeast Schizosaccharomyces pombe, the directions of cell growth change from a monopolar manner to a bipolar manner, which is known as 'New End Take Off' (NETO). Here I report the identification of a gene, arf6(+), encoding an ADP-ribosylation factor small GTPase, that may be essential for NETO. arf6Delta cells completely fail to undergo NETO. arf6p localizes at both cell ends and presumptive septa in a cell-cycle dependent manner. And its polarized localization is not dependent on microtubules, actin cytoskeletons and some NETO factors (bud6p, for3p, tea1p, tea3p, and tea4p). Notably, overexpression of a fast GDP/GTP-cycling mutant of arf6p can advance the timing of NETO. These findings suggest that arf6p functions as a molecular switch for the activation of NETO in fission yeast. |
| 巻・号 | 366(1) |
| ページ | 193-8 |
| 公開日 | 2008-2-1 |
| DOI | 10.1016/j.bbrc.2007.11.117 |
| PII | S0006-291X(07)02536-3 |
| PMID | 18060866 |
| MeSH | ADP-Ribosylation Factor 6 ADP-Ribosylation Factors / metabolism* Cell Enlargement Cell Polarity / physiology Monomeric GTP-Binding Proteins / metabolism* Schizosaccharomyces / cytology* Schizosaccharomyces / physiology* |
| IF | 2.985 |
| 引用数 | 8 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 酵母 | TN214? |