Reference - Detail
RRC ID | 1259 |
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Author | Iwata K, Ogata S, Okumura K, Taguchi H. |
Title | Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds. |
Journal | Biosci Biotechnol Biochem |
Abstract |
It was found that three niacin-related compounds, isonicotinic acid, nicotinamide, and nicotinamide N-oxide, induced granulocytic differentiation in HL-60 cells. We investigated the expression of CD38, which catalyzes the synthesis of cyclic ADP-ribose, a Ca2+ mobilizer, during differentiation by niacin-related compounds. It was found that CD38 was induced by isonicotinic acid, whereas nicotinamide and nicotinamide N-oxide containing an amino group did not induce it. The difference in expression of CD38 may provide some useful information for the elucidation of the mechanisms of cell differentiation. |
Volume | 67(8) |
Pages | 1836-9 |
Published | 2003-8-1 |
DOI | 10.1271/bbb.67.1836 |
PMID | 12951526 |
MeSH | ADP-ribosyl Cyclase / biosynthesis* ADP-ribosyl Cyclase / metabolism ADP-ribosyl Cyclase 1 Antigens, CD / biosynthesis* Antigens, CD / metabolism Cell Differentiation / drug effects Cell Differentiation / physiology Cell Membrane / metabolism Flow Cytometry Gene Expression / drug effects* HL-60 Cells Humans Isonicotinic Acids / pharmacology* Membrane Glycoproteins Niacinamide / analogs & derivatives* Niacinamide / pharmacology Tretinoin / metabolism Tretinoin / pharmacology |
IF | 1.516 |
Times Cited | 6 |
WOS Category | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
Resource | |
Human and Animal Cells | HL60(RCB0041) |