| RRC ID |
12626
|
| Author |
Ogawa M, Yamaji R, Mitani T, Murata Y, Nakao M, Harada N, Nakano Y, Inui H.
|
| Title |
A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
Androgenic compounds induce an interaction between the NH(2)- and COOH-terminal regions (N-C interaction) of androgen receptor (AR). We describe a rapid yeast bioassay for androgenic and anti-androgenic compounds based on androgen-dependent β-catenin-enhanced N-C interaction. The bioassay was also effective at detecting compounds that inhibit the N-C interaction in ways that do not involve binding to the ligand-binding domain.
|
| Volume |
74(9)
|
| Pages |
1965-8
|
| Published |
2010-1-1
|
| DOI |
10.1271/bbb.100323
|
| PII |
JST.JSTAGE/bbb/100323
|
| PMID |
20834141
|
| MeSH |
Androgen Antagonists / analysis*
Androgens / analysis*
Animals
Drug Evaluation, Preclinical / methods*
Humans
Receptors, Androgen / chemistry*
Receptors, Androgen / metabolism
Yeasts
beta Catenin
|
| IF |
1.516
|
| Times Cited |
2
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Yeast |
YPH499? |
