RRC ID 12666
著者 Ishimaru Y, Chiba S, Serikawa T, Sasa M, Inaba H, Tamura Y, Ishimoto T, Takasaki H, Sakamoto K, Yamaguchi K.
タイトル Effects of levetiracetam on hippocampal kindling in Noda epileptic rats.
ジャーナル Brain Res
Abstract In order to clarify the seizure susceptibility of Noda epileptic rat (NER) and the antiepileptic effects of levetiracetam (LEV), we performed electrical hippocampal kindling in NERs compared with Wistar rats (experiment 1), and hippocampal kindling in NERs with LEV administration (experiment 2). In experiment 1, electrical stimulation was administered to the right dorsal hippocampus of NERs and Wistar rats once per day. In experiment 2, NERs were randomly assigned to group L (LEV administration) and C (saline administration). Following daily administration of LEV (240 mg/kg, i.p.) to group L and saline to group C, hippocampal kindling was performed from the 5th day of consecutive LEV or saline administration. As a result of experiment 1, all NERs exhibited stage 5 (falling) or stage 6 seizure (running/jumping, subsequent seizure) from the first electrical stimulation. In experiment 2, LEV suppressed development of hippocampal kindling, increased the afterdischarge threshold of the hippocampus and inhibited stage 6 seizures in NER. Although LEV prolonged the afterdischarge duration at the first stage 5 seizure significantly, there was a tendency to prolong the latency to generalization by LEV. These findings indicate that NER is susceptible not only to limbic seizures but also to brainstem seizures. Furthermore, LEV may have inhibitory effects not only on the hippocampus but also on other neuronal pathways to secondary generalization in this rat model.
巻・号 1309
ページ 104-9
公開日 2010-1-14
DOI 10.1016/j.brainres.2009.10.056
PII S0006-8993(09)02293-8
PMID 19879253
MeSH Animals Anticonvulsants / pharmacology* Brain Stem / drug effects Brain Stem / physiopathology Disease Models, Animal Disease Progression Drug Administration Schedule Electric Stimulation Epilepsy / drug therapy* Epilepsy / genetics Epilepsy / physiopathology Functional Laterality / drug effects Functional Laterality / physiology Genetic Predisposition to Disease / genetics Hippocampus / drug effects* Hippocampus / physiopathology Kindling, Neurologic / drug effects* Kindling, Neurologic / genetics Levetiracetam Male Neural Inhibition / drug effects Neural Inhibition / physiology Neural Pathways / drug effects Neural Pathways / physiopathology Piracetam / analogs & derivatives* Piracetam / pharmacology Rats Rats, Mutant Strains Rats, Wistar Treatment Outcome
IF 2.733
引用数 9
WOS 分野 NEUROSCIENCES
リソース情報
ラット NER/Kyo(strainID=26)