論文 - 詳細
| RRC ID | 12713 |
|---|---|
| 著者 | Nishimura I, Chano T, Kita H, Matsusue Y, Okabe H. |
| タイトル | RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism. |
| ジャーナル | J Biol Chem |
| Abstract |
RB1-inducible coiled-coil 1 (RB1CC1) functions in various processes, such as cell growth, differentiation, senescence, apoptosis, and autophagy. The conditional transgenic mice with cartilage-specific RB1CC1 excess that were used in the present study were made for the first time by the Cre-loxP system. Cartilage-specific RB1CC1 excess caused dwarfism in mice without causing obvious abnormalities in endochondral ossification and subsequent skeletal development from embryo to adult. In vitro and in vivo analysis revealed that the dwarf phenotype in cartilaginous RB1CC1 excess was induced by reductions in the total amount of cartilage and the number of cartilaginous cells, following suppressions of type II collagen synthesis and Erk1/2 signals. In addition, we have demonstrated that two kinds of SNPs (T-547C and C-468T) in the human RB1CC1 promoter have significant influence on the self-transcriptional level. Accordingly, human genotypic variants of RB1CC1 that either stimulate or inhibit RB1CC1 transcription in vivo may cause body size variations. |
| 巻・号 | 286(51) |
| ページ | 43925-43932 |
| 公開日 | 2011-12-23 |
| DOI | 10.1074/jbc.M111.264192 |
| PII | S0021-9258(20)68485-X |
| PMID | 22049074 |
| PMC | PMC3243532 |
| MeSH | Animals Autophagy-Related Proteins Body Size Cartilage / metabolism Chondrocytes / cytology* Collagen Type II / metabolism* Crosses, Genetic Dwarfism / genetics Gene Expression Regulation Humans Intracellular Signaling Peptides and Proteins / metabolism* Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase 1 / metabolism Mitogen-Activated Protein Kinase 3 / metabolism Protein-Tyrosine Kinases / metabolism* |
| IF | 4.238 |
| 引用数 | 6 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pCALNL5 (RDB01862) |
| ヒト・動物細胞 | ATDC5(RCB0565) |