RRC ID |
127
|
著者 |
Blizard DA, Wada Y, Onuki Y, Kato K, Mori T, Taniuchi T, Hosokawa H, Otobe T, Takahashi A, Shisa H, Hiai H, Makino J.
|
タイトル |
Use of a standard strain for external calibration in behavioral phenotyping.
|
ジャーナル |
Behav Genet
|
Abstract |
The present paper evaluates the inclusion of a standard strain or outbred stock in multi-strain behavioral phenotyping protocols to perform the same role as the external standard in biochemical assay procedures. As potential standards, the F344 inbred strain and an outbred stock of Long Evans were tested with three other inbred strains. To evaluate the influence of rearing conditions on phenotype stability, one group of F344s was born at the University of Tsukuba, another, bred elsewhere and delivered to Tsukuba at 4 weeks of age. All animals were tested in open-field (OF), runway emergence (RE) and digging tests as adults. The results showed no influence of breeding or transportation history on OF and RE behavior of the two F344 groups, while there was evidence that digging behavior may be affected by the different rearing experience. The inclusion of a 'standard strain or stock' in phenotyping protocols involving multiple inbred strains or lines of rats, mice and flies has obvious advantages by providing a reference point for inter-laboratory comparisons. The properties of inbred strains and outbred stocks favorable to their use as standards are discussed.
|
巻・号 |
35(3)
|
ページ |
323-32
|
公開日 |
2005-5-1
|
DOI |
10.1007/s10519-005-3224-1
|
PMID |
15864447
|
MeSH |
Animals
Calibration
Crosses, Genetic
Defecation / physiology
Genetics, Behavioral / methods*
Motor Activity / genetics*
Observer Variation
Phenotype
Rats
Rats, Inbred F344 / genetics*
Rats, Inbred Strains
Rats, Long-Evans / genetics*
Reaction Time
Species Specificity
|
IF |
2.231
|
引用数 |
11
|
WOS 分野
|
PSYCHOLOGY, MULTIDISCIPLINARY
GENETICS & HEREDITY
BEHAVIORAL SCIENCES
|
リソース情報 |
ラット |
LE/Stm(strainID=265)
THE/Utp(strainID=516)
TLE/Utp(strainID=515) |