論文 - 詳細
RRC ID | 1320 |
---|---|
著者 | Hashimoto K, Araki K, Osaki M, Nakamura H, Tomita K, Shimizu E, Ito H. |
タイトル | MCM2 and Ki-67 expression in human lung adenocarcinoma: prognostic implications. |
ジャーナル | Pathobiology |
Abstract |
OBJECTIVE:The expressions of minichromosome maintenance protein 2 (MCM2), Ki-67, and p53 were examined to analyze their pathobiological significance in human lung adenocarcinomas. METHODS:We performed Western blot analysis in six human lung adenocarcinoma cell lines and immunohistochemistry in 145 surgically removed adenocarcinomas to examine the MCM2 expression. Labeling indices (LIs; %) of MCM2, Ki-67, and p53 in the tumor cells were compared with clinicopathological profiles and overall survival rates. RESULTS:MCM2 protein was detected in all cell lines examined, with specific bands. MCM2 LIs were significantly correlated with sex, histological type, differentiation, pathological stage, and LIs of Ki-67 and p53 (p < 0.05). Significantly higher LIs of MCM2 and Ki-67 were noted in the 122 non-pure bronchioloalveolar carcinomas than in the 23 pure bronchioloalveolar carcinomas (p < 0.01), and the prognosis was poorer in the former than in the latter (p < 0.01). Sex, pathological stage, and high LIs of MCM2 and/or Ki-67 were independent prognostic factors (p < 0.05). CONCLUSION:High LIs of MCM2 and/or Ki-67 suggest a poor prognosis in patients with lung adenocarcinoma (non-pure bronchioloalveolar carcinoma). |
巻・号 | 71(4) |
ページ | 193-200 |
公開日 | 2004-1-1 |
DOI | 10.1159/000078673 |
PII | 78673 |
PMID | 15263808 |
MeSH | Adenocarcinoma, Bronchiolo-Alveolar / metabolism* Adenocarcinoma, Bronchiolo-Alveolar / mortality Adenocarcinoma, Bronchiolo-Alveolar / pathology Adult Aged Aged, 80 and over Biomarkers, Tumor / metabolism Blotting, Western Cell Cycle Proteins / metabolism* Cell Line, Tumor Female Humans Immunoenzyme Techniques Ki-67 Antigen / metabolism* Lung Neoplasms / metabolism* Lung Neoplasms / mortality Lung Neoplasms / pathology Male Middle Aged Minichromosome Maintenance Complex Component 2 Neoplasm Staging Nuclear Proteins / metabolism* Prognosis Survival Rate |
IF | 1.985 |
引用数 | 40 |
WOS 分野 | PATHOLOGY CELL BIOLOGY |
リソース情報 | |
ヒト・動物細胞 | A549(RCB0098) PC-14(RCB0446) RERF-LC-AI(RCB0444) |