| RRC ID |
138
|
| 著者 |
Kuramoto T, Morimura K, Nomoto T, Namiki C, Hamada S, Fukushima S, Sugimura T, Serikawa T, Ushijima T.
|
| タイトル |
Sparse and wavy hair: a new model for hypoplasia of hair follicle and mammary glands on rat chromosome 17.
|
| ジャーナル |
J Hered
|
| Abstract |
Mutant animals in the skin and hair have been used to identify important genes in biomedical research. We describe a new mutant rat, sparse and wavy hair (swh), that spontaneously arose in a colony of inbred WTC rats. The mutant phenotype was characterized by sparse and wavy hair, which was most prominent at age 3-4 weeks, and was inherited in an autosomal recessive manner. The swh/swh rats showed impaired gain of body weight, and their hair follicles were reduced both in number and size, associated with hypoplasia of the sebaceous glands and the subcutaneous fat tissue. Female swh/swh rats were unable to suckle their offspring. Their mammary glands were hypoplastic, and differentiation of mammary epithelial and myoepithelial cells was impaired. Linkage analysis of 579 backcross rats localized the swh locus to a .35-cM region between D17Rat131 and D17Rat50 in the distal end of rat Chr 17. The swh locus spanned the 3.7-Mb genomic region where 24 genes have been mapped and corresponded to the centromere region of the mouse Chr 2 or the region of the human Chr 10p11.1-p14. None of the genes or loci described in mouse or human hair and skin diseases mapped to these regions. These findings suggest that the rat swh is a novel mutation associated with impaired development of the skin appendages, such as hair follicles, sebaceous glands, and mammary glands, and will provide an experimental model to clarify a gene and mechanisms for development of skin appendages.
|
| 巻・号 |
96(4)
|
| ページ |
339-45
|
| 公開日 |
2005-1-1
|
| DOI |
10.1093/jhered/esi053
|
| PII |
esi053
|
| PMID |
15829729
|
| MeSH |
Animals
Chromosome Mapping*
Fibrocystic Breast Disease / genetics
Fibrocystic Breast Disease / pathology
Fibrocystic Breast Disease / veterinary
Hair / pathology
Hair / physiology*
Hair Diseases / genetics
Hair Diseases / pathology
Hair Diseases / veterinary*
Hair Follicle / pathology*
Mammary Glands, Animal / pathology*
Mutation
Rats
Rodent Diseases / genetics*
Rodent Diseases / pathology
|
| IF |
2.809
|
| 引用数 |
2
|
|
WOS 分野
|
GENETICS & HEREDITY
EVOLUTIONARY BIOLOGY
|
| リソース情報 |
| ラット |
WTC/Kyo(strainID=18)
WTC-swh/Kyo(strainID=539) |
